G9518

Gemfibrozil

PPARα and PPARγ agonist, powder

• Synonym(s): 2,2-Dimethyl-5-(2,5-dimethylphenoxy)pentanoic acid, 2,2-Dimethyl-5-(2,5-xylyloxy)valeric acid, 5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic acid
• Empirical Formula (Hill Notation): C₁₅H₂₂O₃
• CAS Number: 25812-30-0
• Molecular Weight: 250.33
• NACRES: NA.77
• PubChem Substance ID: 24895377
• UNSPSC Code: 12352200
• EC Number: 247-280-2
• MDL number: MFCD00079335
• Form: powder

Properties

• Product Name: Gemfibrozil,
• form: powder
• Quality Segment: 100
• SMILES string: Cc1ccc(C)c(OCCCC(C)(C)C(O)=O)c1
• InChI: 1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)
• InChI key: HEMJJKBWTPKOJG-UHFFFAOYSA-N
• Gene Information: human ... PPARA(5465)

Description

General description

Gemfibrozil is a fibric acid derivative and a hypolipidemic drug. Gemfibrozil serves as a ligand for PPARα (peroxisome proliferator-activated receptor α).[1][2]

Application

Gemfibrozil has been used to to study its effects on cell cycle progression in yeast.[3] It has been used to study the effects of fibrates on cell proliferation and gene expression in human cell lines.[1]

Biochem/physiol Actions

Gemfibrozil selectively increases Apolipoprotein A-I levels.[4] In yeast cells, application of gemfibrozil delays the start of DNA replication.[3] It is used as a therapeutic agent for dyslipidemia.[1]

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 + P330 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves