G5017

Glycophorin Predominantly glycophorin A from blood type MN

lyophilized powder

• CAS Number: 76416-15-4
• MDL number: MFCD00042735
• NACRES: NA.61
• UNSPSC Code: 12352202
• Form: lyophilized powder
• Biological source: human blood (type MN)

Properties

• biological source: human blood (type MN)
• Quality Segment: 200
• form: lyophilized powder
• solubility: soluble 1.00-1.10 mg/mL, H₂O: soluble, clear to hazy
• UniProt accession no.: P02724
• storage temp.: −20°C
• Gene Information: human ... GYPA(2993)

Description

General description

Glycophorin (GYPA), a sialoglycoprotein, is present in human erythrocytes that carry antigens M and N of the MN blood group. The GYPA gene is mapped to human chromosome 4q31.21.[1]

Glycophorin A cconsists of a glycosylated extracellular domain, a single transmembrane α-helix and a cytoplasmic COOH-terminal domain.[2]

Application

Glycophorin A (GpA) is used as a model system for extensive experimental, theoretical, and simulation studies focusing on TM protein association.[3] Glycophorin A is used to study the mechanism of kinase activation in the receptor for colony-stimulating factor 1.[4] It is used to analyse glycoproteins separated by two-dimensional gel electrophoresis.[5]

Glycophorin Predominantly glycophorin A from blood type MN has been used:

• as a standard in Amide-80 column size-based separation for the characterization of plasma-type O-linked sugar chains[6]
• to screen the P. falciparum phage library using biopanning method[7],
• as a phosphocholine-free component to test its reactivity with antibodies over a saccharide-bound enzyme-linked immunosorbent assay (ELISA)[8]

Biochem/physiol Actions

A membrane glycoprotein with several isoforms that interact with other membrane proteins to confer shape and antigenicity to erythrocytes.

Glycophorin (GYPA) is involved in the mode of entry of the Plasmodium falciparum parasite into erythrocytes.[9] It is also implicated in intraplaque hemorrhage as well as in the macrophage infiltration in coronary atheromas.[10]

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable