E3148

Endomorphin 2

• Empirical Formula (Hill Notation): C₃₂H₃₇N₅O₅
• CAS Number: 141801-26-5
• Molecular Weight: 571.67
• UNSPSC Code: 12352200
• PubChem Substance ID: 329799042
• MDL number: MFCD01321064

Properties

• storage temp.: −20°C
• SMILES string: N[C@@H](Cc1ccc(O)cc1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](Cc4ccccc4)C(N)=O
• InChI: 1S/C32H37N5O5/c33-25(18-23-13-15-24(38)16-14-23)32(42)37-17-7-12-28(37)31(41)36-27(20-22-10-5-2-6-11-22)30(40)35-26(29(34)39)19-21-8-3-1-4-9-21/h1-6,8-11,13-16,25-28,38H,7,12,17-20,33H2,(H2,34,39)(H,35,40)(H,36,41)/t25-,26-,27-,28-/m0/s1
• InChI key: XIJHWXXXIMEHKW-LJWNLINESA-N
• Gene Information: human ... OPRM1(4988) ; mouse ... OPRM1(18390) ; rat ... OPRM1(25601)

Description

General description

Endomorphin 2 is an endogenous ligand for μ-opioid receptor (MOR). It is a neuropeptide and has the sequence Tyr-Pro-Phe-Phe-NH2. It has a greater affinity for MOR1 receptor than MOR2. It resides in primary sensory afferent fibers, and might be the predominant ligand to regulate pain perception. In dynorphin-induced allodynia mice models, endomorphin has anti-allodynic effects. In tail flick test, it produces short-lived antinociception, which is naloxone-sensitive.

Biochem/physiol Actions

Potent, selective endogenous μ opioid receptor agonist.

Legal Information

Sold under license to US patent number 6,303,578

Safety Information

• Storage Class: 11 - Combustible Solids
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): Eyeshields, Gloves, type N95 (US)