E1906

Anti-EAPII (TTRAP) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-ETS1-associated Protein 2, Anti-TRAF and TNF Receptor Associated Protein
• UNSPSC Code: 12352203
• NACRES: NA.41
• MDL number: MFCD08705452
• Conjugate: unconjugated
• Clone: polyclonal
• Application: WB
• Citations: 1

Properties

• biological source: rabbit
• Quality Level: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~41 kDa by calculation
• species reactivity: human
• technique(s): western blot: 1:1,000-1:5,000

Description

Immunogen

peptide corresponding to the human EAPII (amino acids 11-28).

Application

Anti-EAPII (TTRAP) antibody produced in rabbit is suitable for western blot analysis at a working dilution of 1:1000-1:5000.

Biochem/physiol Actions

Ets proteins are a family of conserved sequence specific DNA-binding proteins. They function as transcription factors with roles in differentiation, lymphoid cell development, invasiveness, and angiogenesis. ETS1-associated protein II (EAPII) interacts with ETS1 and other Ets proteins (ETS2 and FLI1). EAPII is mainly localized to the nucleus of mammalian cells. EAPII negatively modulates the transcriptional activity of ETS1. It reduces synergistic transactivation by ETS1 and AP-1. Re-expression of EAPII prevents the migration of epithelial cancer cells. It does not affect cell viability.

Physical form

Solution of 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• flash_point_f: Not applicable
• flash_point_c: Not applicable