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Merck

D9035

Diazoxide

≥98% (TLC), powder, ATP-sensitive K⁺ channel activator

Synonym(s):

7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide

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250 MG

CZK 3,290.00

1 G

CZK 8,460.00

5 G

CZK 32,300.00

CZK 3,290.00

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About This Item

Empirical Formula (Hill Notation):
C8H7ClN2O2S
CAS Number:
364-98-7
Molecular Weight:
230.67
NACRES:
NA.77
PubChem Substance ID:
24277831
UNSPSC Code:
12352119
EC Number:
206-668-1
MDL number:
MFCD00078578
Form:
powder
Quality level:
100

Key Documents

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Product Name

Diazoxide,

InChI key

GDLBFKVLRPITMI-UHFFFAOYSA-N

InChI

1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)

SMILES string

CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1

form

powder

solubility

0.1 M NaOH: soluble, H2O: insoluble, methanol: soluble

originator

Schering Plough

Quality Level

100

Gene Information

human ... KCNA1(3736), KCNJ11(3767), KCNJ8(3764), KCNMA1(3778)
mouse ... Kcnj1(56379), Kcnj11(16514)
rat ... Gria1(50592), Kcna1(24520), Kcnj1(24521), Kcnj11(83535), Kcnj8(25472)

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1 of 4

This Item
D09500001186000C9847
Diazoxide

Sigma-Aldrich

D9035

Diazoxide

Diazoxide European Pharmacopoeia (EP) Reference Standard

D0950000

Diazoxide

Diazoxide United States Pharmacopeia (USP) Reference Standard

USP

1186000

Diazoxide

Cyclothiazide

Sigma-Aldrich

C9847

Cyclothiazide

form

powder

form

-

form

-

form

powder

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

200

solubility

0.1 M NaOH: soluble, methanol: soluble, H2O: insoluble

solubility

-

solubility

-

solubility

-

originator

Schering Plough

originator

-

originator

-

originator

Eli Lilly

Gene Information

human ... KCNA1(3736), KCNJ11(3767), KCNJ8(3764), KCNMA1(3778)
mouse ... Kcnj1(56379), Kcnj11(16514)
rat ... Gria1(50592), Kcna1(24520), Kcnj1(24521), Kcnj11(83535), Kcnj8(25472)

Gene Information

human ... KCNJ11(3767), KCNJ8(3764)

Gene Information

human ... KCNJ11(3767), KCNJ8(3764)

Gene Information

human ... CA1(759), CA4(762), GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893)
rat ... Gria1(50592)

General description

Diazoxide is a nondiuretic benzothiadiazine, which is used for the treatment of hypoglycemia, von Gierke′s disease, acute and malignant hypertension. It acts as a beta cell KATP channel opener. Diazoxide prevents the secretion of insulin.

Application

Diazoxide has been used for diazoxide infusion. It has also been used to prevent depolarization for K+-induced exocytosis.

Biochem/physiol Actions

Selective ATP-sensitive K+ channel activator in both vascular smooth muscle and pancreatic β-cells; antihypertensive.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL3550
WXBF2299V
BCCF3412
BCCB0466
BCBX4929

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Diazoxide Attenuates Ischemic Myocardial Injury in a Porcine Model
Sarja H, et al.
The Heart Surgery Forum (2017)
Stability of diazoxide in extemporaneously compounded oral suspensions
Friciu M, et al.
Testing, 11(10), e0164577-e0164577 (2016)
N D'hahan et al.
Proceedings of the National Academy of Sciences of the United States of America, 96(21), 12162-12167 (1999-10-16)
The pharmacological phenotype of ATP-sensitive potassium (K(ATP)) channels is defined by their tissue-specific regulatory subunit, the sulfonylurea receptor (SUR), which associates with the pore-forming channel core, Kir6.2. The potassium channel opener diazoxide has hyperglycemic and hypotensive properties that stem from
Glucose-dependent granule docking limits insulin secretion and Is decreased in human type 2 diabetes
Gandasi NR, et al.
Cell Metabolism, 27(2), 470-478 (2018)
T Grimmsmann et al.
British journal of pharmacology, 123(5), 781-788 (1998-04-16)
1. The direct effects of diazoxide on mitochondrial membrane potential, Ca2+ transport, oxygen consumption and ATP generation were investigated in mouse pancreatic B-cells and rat liver mitochondria. 2. Diazoxide, at concentrations commonly used to open adenosine 5'-triphosphate (ATP)-dependent K+-channels (K(ATP)
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