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C9373

CP-96345

≥98% (HPLC)

Synonym(s):

(2S,3S)-cis-2-(Diphenylmethyl)-N-[(2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine

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About This Item

Empirical Formula (Hill Notation):
C28H32N2O
CAS Number:
132746-60-2
Molecular Weight:
412.57
NACRES:
NA.77
PubChem Substance ID:
329775205
UNSPSC Code:
12352200
MDL number:
MFCD00900615
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white

solubility

DMSO: 24 mg/mL

storage temp.

room temp

SMILES string

COC1=CC=CC=C1CN[C@@H]2[C@H](C(C3=CC=CC=C3)C4=CC=CC=C4)N5CCC2CC5

InChI

1S/C28H32N2O/c1-31-25-15-9-8-14-24(25)20-29-27-23-16-18-30(19-17-23)28(27)26(21-10-4-2-5-11-21)22-12-6-3-7-13-22/h2-15,23,26-29H,16-20H2,1H3/t27-,28-/m0/s1

InChI key

FLNYLINBEZROPL-NSOVKSMOSA-N

Biochem/physiol Actions

CP-96345 is a selective NK1 antagonist.
CP-96345 is a selective NK1 antagonist. CP96345 inhibits substance P-induced salivation in the rat by classical in vivo bioassay, but did not inhibit NK2, NK3, or numerous other receptors.

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CP-96345 ≥98% (HPLC)

Sigma-Aldrich

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Sigma-Aldrich

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CP-135807 ≥98% (HPLC)

Sigma-Aldrich

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Apcin ≥98% (HPLC)

Sigma-Aldrich

SML1503

Apcin

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

solubility

DMSO: 24 mg/mL

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: ≥5 mg/mL

solubility

DMSO: 25 mg/mL, clear

color

white

color

white to beige

color

brown-red

color

white to beige

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
049K4703V
049K4703

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Nasser Haddjeri et al.
European journal of pharmacology, 600(1-3), 64-70 (2008-10-22)
Substance P (neurokinin-1; NK1) receptor antagonists represent a putative new class of antidepressant/anxiolytic drugs. Using in vivo electrophysiological paradigms in rats, this study examined the effects of acute, sub-acute and long-term administration of these drugs on the firing of rat
Stefan Nessler et al.
Journal of neuroimmunology, 179(1-2), 1-8 (2006-08-15)
Substance P (SP) is an excitatory neurotransmitter in the central and peripheral nervous system. Most of its physiological functions are mediated through binding to the neurokinin-1 receptor (NK-1R). Recently, proinflammatory properties of SP have been described. In this study we
L M Katz et al.
Journal of veterinary pharmacology and therapeutics, 26(5), 361-368 (2003-11-25)
Substance P (SP), a potent vasodilator, has been detected in equine digital sensory-motor nerves. The aim of the study was to characterise the functional responses of equine digital blood vessels to exogenous SP. Pre-constricted equine digital arteries (EDA) and veins
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Global Trade Item Number

SKUGTIN
C9373-5MG04061832897745
C9373-25MG04061832897738

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