C5688
Complement factor D from human plasma
90-110 μg/mL in PBS, pH 7.2, ≥90% (SDS-PAGE)
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 10 μg | Please contact Customer Service for Availability | CZK 10,100.00 CZK 8,585.00 |
About This Item
Form:
liquid
Assay:
≥90% (SDS-PAGE)
Biological source:
human plasma
CZK 8,585.00
List PriceCZK 10,100.00Save 15%Please contact Customer Service for Availability
Application
Complement factor D is a serine protease essential for the activation of the alternative pathway in the complement system. Research of complement factor D has revealed that a self inhibitory loop is responsible for switch from a resting to active state. Additionally, recent research has linked a complement factor D gene, single nucleotide polymorphism (SNP) rs3826945, with age-related macular degeneration (AMD). In these AMD cases there was a significant increase in plasma complement factor D concentration, even though previous research has shown no association between complement factor D SNP genes and AMD.
Biochem/physiol Actions
Complement factor D is a serine protease with structural homologies with chymotrypsin. In the complement cascade, factor D cleaves complement factor B in complex with activated complement component C3. It is identical to adipsin, which is expressed in adipose tissue.
Analysis Note
Source plasma tested for HBSAg, HCV, HBC, syphillis, and HIV-1/HIV-2
Other Notes
View more information on the complement pathway at www.sigma-aldrich.com/enzymeexplorer
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
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This Item | |||
|---|---|---|---|
| assay ≥90% (SDS-PAGE) | assay ≥90% (SDS-PAGE) | assay ≥90% (SDS-PAGE) | assay ≥95% (SDS-PAGE) |
| biological source human plasma | biological source human plasma | biological source human serum | biological source human |
| concentration 90-110 μg/mL in PBS, pH 7.2 | concentration 1 mg/mL in PBS, pH 7.2 | concentration 1 mg/mL in PBS, pH 7.2 | concentration - |
| form liquid | form liquid | form solution | form liquid |
| shipped in dry ice | shipped in dry ice | shipped in dry ice | shipped in dry ice |
| storage temp. −70°C | storage temp. −70°C | storage temp. −70°C | storage temp. −70°C |
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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M A Niemann et al.
Journal of immunology (Baltimore, Md. : 1950), 132(2), 809-815 (1984-02-01)
The monoclonal antibodies (MAb) were studied for their binding specificities and their effects on the hemolytic and proteolytic activities of human D. One Mab, FD10-1, was obtained from mice immunized with native D; the other, JA4-2, was similarly obtained from
Chloe M Stanton et al.
Investigative ophthalmology & visual science, 52(12), 8828-8834 (2011-10-18)
To examine the role of complement factor D (CFD) in age-related macular degeneration (AMD) by analysis of genetic association, copy number variation, and plasma CFD concentrations. Single nucleotide polymorphisms (SNPs) in the CFD gene were genotyped and the results analyzed
Jiexi Zeng et al.
Molecular vision, 16, 2273-2278 (2010-12-09)
Age-related macular degeneration (AMD) is the most common cause of irreversible central vision loss worldwide. Research has linked AMD susceptibility with dysregulation of the complement cascade. Typically, complement factor H (CFH), complement factor B (CFB), complement component 2 (C2), and
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C5688-10UG | 04061833384275 |