C4163

α-Crystallin from bovine eye lens

lyophilized powder

• Synonym(s): alpha-Crystallin
• CAS Number: 11046-99-4
• UNSPSC Code: 12352202
• NACRES: NA.61
• MDL number: MFCD00070939
• Form: lyophilized powder
• Assay: ≥70% (biuret)
• Biological source: bovine eye (lens)

Properties

• Quality Segment: 200
• biological source: bovine eye (lens)
• assay: ≥70% (biuret)
• form: lyophilized powder
• technique(s): cell culture | mammalian: suitable
• UniProt accession no.: P02470, P02510
• storage temp.: −20°C
• Gene Information: bovine ... CRYAA(281718), CRYAB(281719)

Description

Application

α-Crystallin is a lens protein that contains two homologous subunits: αA- and αB-crystallins. α-Crystallin displays chaperone-like activity and plays an important role in maintaining lens transparency. It has been noted that in diabetic conditions of rats there is a decline in the chaperone activity of α-Crystallin. Research has shown that a dietary antioxidant, curcumin, can prevent this loss of chaperone activity.

Biochem/physiol Actions

α-Crystallin is a small heat-shock protein that has chaperone-like activity, preventing protein aggregation in vitro. Point mutations in α-crystallin genes are believed to be responsible for hereditary cataract development.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)