C1688

Anti-C-Reactive Protein antibody, Mouse monoclonal

clone CRP-8, purified from hybridoma cell culture

• Synonym(s): Monoclonal Anti-C-Reactive Protein antibody produced in mouse, Anti-CRP
• UNSPSC Code: 12352203
• NACRES: NA.41
• MDL number: MFCD00162183
• Conjugate: unconjugated
• Clone: CRP-8, monoclonal
• Application: DB, ELISA (i), WB
• Citations: 29

Properties

• biological source: mouse
• Quality Segment: 200
• conjugate: unconjugated
• antibody form: purified from hybridoma cell culture
• antibody product type: primary antibodies
• clone: CRP-8, monoclonal
• mol wt: antigen 24 kDa
• contains: 15 mM sodium azide
• species reactivity: human
• technique(s): dot blot: suitable, indirect ELISA: 1:40,000-80,000, western blot: 1:200-400
• isotype: IgG1
• UniProt accession no.: P02741
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... CRP(1401)

Description

General description

C-reactive protein (CRP) is a member of the pentraxin family of proteins and synthesized by the liver. It is also known as PTX1. The CRP gene is mapped to human chromosome 1q23.2.

Immunogen

human C-reactive protein.

Application

• It has been used in immunoblotting assay, to identify monomeric CRP.
• In time-resolved fluorometric assay.

Monoclonal Anti-C-Reactive Protein antibody produced in mouse is suitable for the following:

• dot blot analysis
• indirect ELISA at a working dilution of 1:40,000
• western blotting at a working dilution of 1:200

Biochem/physiol Actions

C-reactive protein (CRP) shows essential scavenging and metabolic activity and is also associated with defence mechanism. It activates the complement pathway by binding to calcium-dependent exogenous and autologous molecules containing phosphocholine (PC). It may have pathogenic effects and is a practical prognostic marker in patients with hepatocellular carcinoma (HCC). The CRP diagnostic value is higher for acute pyelonephritis than lower urinary tract infection. Thus, it helps in differentiating between upper and lower urinary tract infection. It is considered best for predicting the risk of cardiovascular disease..

The antibody recognizes an epitope located on the 24 kDa subunit of denatured and reduced CRP. It does not cross-react with human serum amyloid P component (SAP), human haptoglobin, human α₁-acid glycoprotein, human IgG, and CRP from Limulus.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable