C1538
Complement C8 deficient serum human
for complement assays
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| Size/SKU | Availability | Price |
|---|---|---|
1 mL | Please contact Customer Service for Availability | CZK 13,600.00 |
About This Item
NACRES:
NA.61
UNSPSC Code:
12352202
Biological source:
human
Origin:
USA origin
Form:
solution
Shipped in:
dry ice
CZK 13,600.00
Please contact Customer Service for Availability
Application
Complement C8 is one of the end terminals of the complement system contained in the membrane attack complex (MAC). A deficiency of C8 may result in an increased susceptibility to Neisseria meningitidis. The most common mutation resulting in a C8 deficiency is a C to T transition in exon 9 of the C8 beta gene. Recent research however, has also discovered that two separate heterogeneous mutations may result in C8 deficiency in patients displaying recurrent meningococcal meningitis. These mutations are a duplication mutation on exon 7 and a mutation on exon 3.
Biochem/physiol Actions
Serum naturally deficient in C8 may actually contain some C8, though in greatly reduced quantity. Terminal complement complex is present at trace levels in such sera.[1]
Physical form
Supplied as a solution in PBS, pH 7.3
Analysis Note
C8 is depleted by immunoadsorption as judged by a highly sensitive hemolytic assay.
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
1 of 1
This Item | |||
|---|---|---|---|
| biological source human | biological source human | biological source human | biological source human |
| origin USA origin | origin - | origin - | origin - |
| form solution | form solution | form solution | form liquid |
| technique(s) activity assay: suitable | technique(s) activity assay: suitable | technique(s) activity assay: suitable | technique(s) activity assay: suitable |
| storage temp. −70°C | storage temp. −70°C | storage temp. −70°C | storage temp. −70°C |
| shipped in dry ice | shipped in dry ice | shipped in dry ice | shipped in dry ice |
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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