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C0868

Chromeceptin

≥98% (HPLC), solid

Synonym(s):

2-Amino-3-cyano-7-dimethylamino-4-(3-trifluoromethylphenyl)-4H-chromene, 94G6

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5 mg
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CZK 4,840.00

About This Item

Empirical Formula (Hill Notation):
C19H16F3N3O
CAS Number:
331859-86-0
Molecular Weight:
359.35
NACRES:
NA.77
PubChem Substance ID:
24724431
UNSPSC Code:
51111800
MDL number:
MFCD00815850
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100

CZK 4,840.00

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Quality Level

100

assay

≥98% (HPLC)

form

solid

color

yellow to brown

solubility

H2O: <2 mg/mL, DMSO: >20 mg/mL

storage temp.

−20°C

SMILES string

CN(C)c1ccc2C(c3cccc(c3)C(F)(F)F)C(C#N)=C(N)Oc2c1

InChI

1S/C19H16F3N3O/c1-25(2)13-6-7-14-16(9-13)26-18(24)15(10-23)17(14)11-4-3-5-12(8-11)19(20,21)22/h3-9,17H,24H2,1-2H3

InChI key

GVINXTXGDDSXFQ-UHFFFAOYSA-N

Biochem/physiol Actions

Chromeceptin binds to multifunctional protein 2 (MFP-2); inhibits Insulin-like growth factor 2 (IGF2) signaling.
Chromeceptin inhibits Insulin-like growth factor 2 (IGF2) signaling by a process that begins with chromeceptin binding to multifunctional protein 2 (MFP-2). This interaction stimulates the expression of IGF binding protein 1 (IGFBP-1) and suppressor of cytokine signaling-3 (SOCS-3), both of which activate signal transducers and activators of transcription 6 (STAT6) to attenuate IGF signals.

Features and Benefits

This compound is featured on the InsR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item
SML1799SML2950SML2922
Chromeceptin &#8805;98% (HPLC), solid

Sigma-Aldrich

C0868

Chromeceptin

UCPH-102 &#8805;98% (HPLC)

Sigma-Aldrich

SML1799

UCPH-102

E7820 &#8805;98% (HPLC)

Sigma-Aldrich

SML2950

E7820

SEW84 &#8805;98% (HPLC)

Sigma-Aldrich

SML2922

SEW84

form

solid

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

H2O: <2 mg/mL, DMSO: >20 mg/mL

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

color

yellow to brown

color

white to beige

color

white to beige

color

white to beige

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000135148
0000042111
0000021361
0000010949
106K4609

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Articles

InsR

We offers many products related to InsR for your research needs.

Yongmun Choi et al.
Chemistry & biology, 13(3), 241-249 (2006-04-28)
Insulin-like growth factor 2 (IGF2) is a potent mitogen whose deregulation plays a role in developing liver, breast, and prostate cancers. Here, we take a small-molecule approach to investigate molecular pathways that modulate IGF2 signaling, by using chromeceptin, a synthetic
Hyang Sook Seol et al.
Scientific reports, 10(1), 21412-21412 (2020-12-10)
Stemness factors control microRNA expression in cancer stem cells. Downregulation of miR-100 and miR-125b is associated with tumor progression and prognosis of various cancers. Comparing miRNA profiling of patient-derived tumorsphere (TS) and adherent (2D) hepatocellular carcinoma cells, miR-100 and miR-125b
Yongmun Choi et al.
The Journal of biological chemistry, 278(9), 7320-7324 (2002-12-24)
An important step in the postgenomic drug discovery is the construction of high quality chemical libraries that generate bioactive molecules at high rates. Here we report a cell-based approach to composing a focused library of biologically active compounds. A collection

Global Trade Item Number

SKUGTIN
C0868-5MG04061832445205
C0868-25MG04061832445199

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