B6311
BTO-1
≥98% (HPLC), solid
Synonym(s):
5-Cyano-7-nitro-2-benzothiazolecarboxamide-3-oxide
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 5 mg | Please contact Customer Service for Availability | CZK 3,990.00 CZK 3,391.50 |
About This Item
Empirical Formula (Hill Notation):
C9H4N4O4S
CAS Number:
Molecular Weight:
264.22
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
CZK 3,391.50
List PriceCZK 3,990.00Save 15%Please contact Customer Service for Availability
Quality Level
assay
≥98% (HPLC)
form
solid
color
tan
solubility
H2O: <2 mL/mL, DMSO: ≥5 mg/mL
storage temp.
2-8°C
SMILES string
NC(=O)c1sc2c(cc(cc2[n+]1[O-])C#N)[N+]([O-])=O
InChI
1S/C9H4N4O4S/c10-3-4-1-5-7(6(2-4)13(16)17)18-9(8(11)14)12(5)15/h1-2H,(H2,11,14)
InChI key
FKRBAXZAJBBIAJ-UHFFFAOYSA-N
Biochem/physiol Actions
BTO-1 is a polo-like kinase (Plk) inhibitor.
1 of 1
This Item | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form solid | form powder | form powder | form solid |
| Quality Level 100 | Quality Level - | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility H2O: <2 mL/mL, DMSO: ≥5 mg/mL | solubility DMSO: 2 mg/mL, clear | solubility DMSO: 20 mg/mL, clear | solubility DMSO: >10 mg/mL, H2O: insoluble |
| color tan | color white to very dark brown | color white to beige | color white to off-white |
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Keiko Yata et al.
Molecular cell, 45(3), 371-383 (2012-02-14)
Homologous recombination (HR) plays an important role in the maintenance of genome integrity. HR repairs broken DNA during S and G2 phases of the cell cycle but its regulatory mechanisms remain elusive. Here, we report that Polo-like kinase 1 (Plk1)
Mark E Burkard et al.
PLoS biology, 7(5), e1000111-e1000111 (2009-05-27)
Animal cells initiate cytokinesis in parallel with anaphase onset, when an actomyosin ring assembles and constricts through localized activation of the small GTPase RhoA, giving rise to a cleavage furrow. Furrow formation relies on positional cues provided by anaphase spindle
Campbell McInnes et al.
Nature chemical biology, 2(11), 608-617 (2006-10-10)
Polo-like kinases (Plks) have several functions in mitotic progression and are upregulated in many tumor types. Small-molecule Plk inhibitors would be valuable as tools for studying Plk biology and for developing antitumor agents. Guided by homology modeling of the Plk1
Global Trade Item Number
| SKU | GTIN |
|---|---|
| B6311-25MG | 04061832444581 |
| B6311-5MG | 04061832444598 |