B3313
Bicyclol
≥98% (HPLC)
Synonym(s):
4, 4′-dimethoxy-2, 3, 2′, 3′-bis(methylenedioxy)-6-hydroxymethyl-6′-methoxy-carbonyl biphenyl
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About This Item
Empirical Formula (Hill Notation):
C19H18O9
CAS Number:
Molecular Weight:
390.34
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
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Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to off-white
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
SMILES string
COC(=O)c1cc(OC)c2OCOc2c1-c3c(CO)cc(OC)c4OCOc34
InChI
1S/C19H18O9/c1-22-11-4-9(6-20)13(17-15(11)25-7-27-17)14-10(19(21)24-3)5-12(23-2)16-18(14)28-8-26-16/h4-5,20H,6-8H2,1-3H3
InChI key
KXMTXZACPVCDMH-UHFFFAOYSA-N
General description
Bicyclol has anti-inflammatory properties and enhances the prognosis of kidney transplantation. It is involved in the removal of reactive oxygen species and modulates cytokine secretion.
Biochem/physiol Actions
Bicyclol is a anti-hepatitis drug, used in China for chronic hepatitis B and presumably C.
Bicyclol is a anti-hepatitis drug, used in China for chronic hepatitis B and presumably C. The drug appears to protect against liver injury in animals. Recently it was reported that bicyclol induce the expression of hepatic HSP27 and HSP70, and thus consequently inhibits the transcription factor NF-?B-mediated apoptosis and necrosis in liver tissue. It appears that bicyclol induces hepatic HSP27 and HSP70 expression through activating transcription of HSPs genes.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Qinge Ma et al.
Journal of ethnopharmacology, 195, 166-172 (2016-11-15)
Houttuynia cordata is an important traditional Chinese medicine used in heat-clearing and detoxifying, swelling and discharging pus, promoting diuresis and relieving stranguria which recorded in Pharmacopoeia of the people's Republic of China (2015 Edition). H. cordata has been recorded in
Protective effect of bicyclol on acute alcohol-induced liver injury in mice
Zhao J, et al.
European Journal of Pharmacology, 586(1-3), 322-331 (2008)
Effect of Bicyclol tablets on drug induced liver injuries after kidney transplantation
Shang W, et al.
Open Medicine : A Peer-Reviewed, Independent, Open-Access Journal, 12(1), 62-69 (2017)