B2186

BL-1249

≥98% (HPLC)

• Synonym(s): (5,6,7,8-Tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol-5-yl)-phenyl]-amine
• Empirical Formula (Hill Notation): C₁₇H₁₇N₅
• CAS Number: 18200-13-0
• Molecular Weight: 291.35
• NACRES: NA.77
• PubChem Substance ID: 24724415
• UNSPSC Code: 12352200
• MDL number: MFCD08276915
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: protect from light

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: protect from light
• color: pink to brown
• solubility: DMSO: ~17.5 mg/mL, H₂O: insoluble
• storage temp.: −20°C
• SMILES string: C1CCc2c(C1)cccc2Nc3ccccc3-c4nnn[nH]4
• InChI: 1S/C17H17N5/c1-2-8-13-12(6-1)7-5-11-15(13)18-16-10-4-3-9-14(16)17-19-21-22-20-17/h3-5,7,9-11,18H,1-2,6,8H2,(H,19,20,21,22)
• InChI key: YYNRZIFBTOUICE-UHFFFAOYSA-N

Description

General description

BL-1249 is a non-steroid anti-inflammatory drug and an inhibitor of the cyclooxygenase (COX) enzyme.[1]

Application

BL-1249 has been used:

• as an activator of mechano-gated K2P channel in contracted mouse ileum and colon tissues[1]
• as a TWIK related potassium channel (TREK2) modulator and in U-2 OS osteosarcoma cell line[2]
• as a TREK1 and TREK2 activator in mice.[3]

Biochem/physiol Actions

BL-1249 also activates TWIK related potassium channel 2 (TREK2). It interacts with K2P channel at the negatively charged activator site and modulates channel opening.[4]

BL-1249 is a potassium TREK-1 channel activator.

BL-1249 is a putative activator of potassium TREK-1 channel.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335,H413
• pcodes: P273 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves