AC-0335

Prostein (P501S, SLC45A3) (EP381) Rabbit Monoclonal Primary Antibody

• NACRES: NA.41
• UNSPSC Code: 12352203
• Clone: monoclonal
• Technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:200
• Application: IHC (p)
• Citations: -

Properties

• biological source: rabbit
• Quality Level: 500
• antibody form: Ig fraction of antiserum
• clone: monoclonal
• description: For In Vitro Diagnostic Use in Select Regions (See Chart)
• form: buffered aqueous solution
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:200
• shipped in: wet ice
• storage temp.: 2-8°C
• visualization: cytoplasmic

Description

General description

Prostein, also known as P501S, is encoded by the Solute carrier family 45, member 3 (SLC45A3) gene, an androgen-regulated gene and a prostate specific marker expressed in prostatic glandular cells. SLC45A3 is the second most common gene fusion partner in prostate cancers. SLC45A3-ERG and SLC45A3-ELK4 fusion transcripts have been detected in prostate cancer. Loss of prostein expression in SLC45A3-ERG tumors are significantly associated with high Gleason scores and poor clinical outcomes. Prostein immunoreactivity is seen in the majority of primary and metastatic prostate carcinomas. Staining for prostein in conjunction with PSA improves identification of prostatic origin in unknown primary lesions, when compared against prostein or PSA staining alone.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and &< 0.1% Sodium Azide

Analysis Note

IVD

IVD

IVD

RUO

Other Notes

For a copy of the IFU and CofA contact [email protected]

For Technical Service please contact: 800-665-7284 or email: [email protected]

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable