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Anti-ATP13A2 antibody produced in rabbit

Name: Anti-ATP13A2 antibody produced in rabbit
Brand: SIGMA

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-ATPase type 13A2, Anti-PARK9

About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

Citations:

This product is discontinued. Contact Technical Servicefor assistance.

Properties

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~129 kDa

species reactivity

mouse, human

enhanced validation

recombinant expression
Learn more about Antibody Enhanced Validation

concentration

~1 mg/mL

technique(s)

western blot: 1-2 μg/mL using mouse brain extract (S1 fraction), western blot: 2-4 μg/mL using extract of HEk-293T cells expressing human ATP13A2

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ATP13A2(23400)
mouse ... Atp13a2(74772)
rat ... Atp13a2(362645)

Description

General description

ATP13A2 is a member of the P5 family of ATPases which function in the transport of inorganic cations.

ATPase type 13A2 (ATP13A2) is a neuronal P-type ATPAse. The gene is also referref as PARK9 (Parkinson′s disease 9).

Rabbit Anti-ATP13A2 antibody binds to human and mouse ATP13A2.

Application

Rabbit Anti-ATP13A2 antibody has been used for western blot assays.

Biochem/physiol Actions

Mutations in the gene encoding ATPase type 13A2 (ATP13A2) is implicated with a hereditary form of PD associated with dementia, known as Kufor-Rakeb syndrome (KRS). ATP13A2 shows elevated expression levels in brains of sporadic PD patients, suggesting a potential role in the more common forms of Parkinson′s disease.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	HPA050910	HPA049717	HPA031774
Sigma-Aldrich A9607 Anti-ATP13A2 antibody produced in rabbit	Sigma-Aldrich HPA050910 Anti-ATP13A2 antibody produced in rabbit	Sigma-Aldrich HPA049717 Anti-ATP13A1 antibody produced in rabbit	Sigma-Aldrich HPA031774 Anti-ATP13A5 antibody produced in rabbit
Quality Level 200	Quality Level -	Quality Level 100	Quality Level 100
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
technique(s) western blot: 1-2 μg/mL using mouse brain extract (S1 fraction), western blot: 2-4 μg/mL using extract of HEk-293T cells expressing human ATP13A2	technique(s) immunohistochemistry: 1:200- 1:500	technique(s) immunohistochemistry: 1:20- 1:50	technique(s) immunohistochemistry: 1:20- 1:50

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Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Storage Class

12 - Non Combustible Liquids

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ATP13A2 modifies mitochondrial localization of overexpressed TOM20 to autolysosomal pathway.

Yuta Hatori et al.

PloS one, 17(11), e0276823-e0276823 (2022-11-30)

Mutations in ATP13A2 cause Kufor-Rakeb Syndrome (KRS), a juvenile form of Parkinson's Disease (PD). The gene product belongs to a diverse family of ion pumps and mediates polyamine influx from lysosomal lumen. While the biochemical and structural studies highlight its

Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited α-synuclein accumulation and age-dependent sensorimotor deficits.

Patrick J Schultheis et al.

Human molecular genetics, 22(10), 2067-2082 (2013-02-09)

Mutations in ATP13A2 (PARK9), encoding a lysosomal P-type ATPase, are associated with both Kufor-Rakeb syndrome (KRS) and neuronal ceroid lipofuscinosis (NCL). KRS has recently been classified as a rare genetic form of Parkinson's disease (PD), whereas NCL is a lysosomal

Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

Ramirez A, et al.

Nature Genetics, 38(10), 1184-1184 (2006)

View All Related Papers

Global Trade Item Number

SKU	GTIN
A9607-200UL	04061838029775

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