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A9202

Angiotensin Fragment 1-7 acetate salt hydrate

≥90% (HPLC), powder, RAS heptapeptide

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1 mg
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CZK 1,590.00
5 mg
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CZK 4,780.00

About This Item

Empirical Formula (Hill Notation):
C41H62N12O11 · xC2H4O2 · yH2O
Molecular Weight:
899.00 (anhydrous free base basis)
UNSPSC Code:
12352202
PubChem Substance ID:
24891425
NACRES:
NA.77
MDL number:
MFCD00153513
Assay:
≥90% (HPLC)
Form:
powder

CZK 1,590.00

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Product Name

Angiotensin Fragment 1-7 acetate salt hydrate, ≥90% (HPLC), powder

Quality Segment

200

assay

≥90% (HPLC)

form

powder

UniProt accession no.

P01019

storage temp.

−20°C

SMILES string

CCC(C)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(NC(=O)C(CCCNC(N)=N)NC(=O)C(N)CC(O)=O)C(C)C)C(=O)NC(Cc2cnc[nH]2)C(=O)N3CCCC3C(O)=O

InChI

1S/C41H62N12O11/c1-5-22(4)33(38(61)50-29(17-24-19-45-20-47-24)39(62)53-15-7-9-30(53)40(63)64)52-36(59)28(16-23-10-12-25(54)13-11-23)49-37(60)32(21(2)3)51-35(58)27(8-6-14-46-41(43)44)48-34(57)26(42)18-31(55)56/h10-13,19-22,26-30,32-33,54H,5-9,14-18,42H2,1-4H3,(H,45,47)(H,48,57)(H,49,60)(H,50,61)(H,51,58)(H,52,59)(H,55,56)(H,63,64)(H4,43,44,46)

InChI key

PVHLMTREZMEJCG-UHFFFAOYSA-N

Gene Information

human ... AGT(183)

Application

Angiotensin Fragment 1-7 acetate salt hydrate has been used:
  • to evaluate its effects on a rat model of ventilator-induced diaphragmatic dysfunction (VIDD) with neuromuscular blocking agent infusion[1]
  • to unilaterally inject into the lateral preoptic area (LPA) to study its effects on intravesical pressure, arterial pressure, heart rate, and renal conductance in the female rats[2]
  • to study its association with influenza A virus (IAV) infection[3]

Biochem/physiol Actions

Angiotensin fragment 1-7 is a biologically active heptapeptide of the renin-angiotensin system (RAS).[3] It is associated with anti-inflammatory and anti-fibrotic effects in many inflammatory diseases such as asthma, dyslipidemia, renal injury, arthritis, and lung fibrosis. Angiotensin fragment 1-7 acts as a pro-resolving mediator and induces resolution of inflammation via Mas receptor (MasR).[3] It is responsible for relaxation in several vascular beds. Angiotensin fragment 1-7 has a dual action of an angiotensin II type 1 (AT1) receptor agonist and antagonist depending on the presence of angiotensin II. It also serves as a substrate for angiotensin-converting enzyme (ACE). Sometimes, angiotensin fragment 1-7 prevents ACE activity leading to decreased angiotensin II generation and improved bradykinin-induced vasodilatation.[4]

Other Notes

Lyophilized from 0.5% acetic acid

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This Item
A9650A0230A2900
Angiotensin Fragment 1-7 acetate salt hydrate ≥90% (HPLC), powder

Sigma-Aldrich

A9202

Angiotensin Fragment 1-7 acetate salt hydrate

Angiotensin I human acetate salt hydrate ≥90% (HPLC), powder, suitable for mammalian cell culture

Sigma-Aldrich

A9650

Angiotensin I human acetate salt hydrate

Angiotensin IV trifluoroacetate salt ≥95% (HPLC), powder

Sigma-Aldrich

A0230

Angiotensin IV trifluoroacetate salt

[Val5]-Angiotensin II acetate salt hydrate ≥95% (HPLC), powder

Sigma-Aldrich

A2900

[Val5]-Angiotensin II acetate salt hydrate

form

powder

form

powder

form

powder

form

powder

assay

≥90% (HPLC)

assay

≥90% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

200

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Gene Information

human ... AGT(183)

Gene Information

human ... AGT(183)

Gene Information

-

Gene Information

human ... AGTR1(185)
mouse ... AGTR1(11607)
rat ... AGTR1(24180)

UniProt accession no.

P01019

UniProt accession no.

P01019

UniProt accession no.

-

UniProt accession no.

-

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000466787
0000466787
0000325666
0000325666
0000251727

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Global Trade Item Number

SKUGTIN
A9202-5MG04061833401552
A9202-1MG04061826149355

Questions

  1. For how long can Angiotensin 1-7 (A9202) be stored at -20?

    1 answer

    1. This product is not assigned an expiration date. It contains a recommended retest date of approximately 5 years after the quality release date. A recommended retest date is the period of time during which the product is expected to remain within established stability specifications, provided that it has been stored under defined conditions. After the Retest Date, product samples should be examined to ensure that the product is still in compliance with the established specifications. For more information, you may access the "Product Dating Information" document under "ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS" at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/US/en/life-science/quality-and-regulatory-management/quality-services.

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