A9106

ADP-ribosylcyclase

1000-3000 units/mg protein

• Synonym(s): Adenosine diphosphoribose cyclase from Aplysia californica
• CAS Number: 135622-82-1
• UNSPSC Code: 12352204
• NACRES: NA.54
• MDL number: MFCD00212894
• Specific activity: 1000-3000 units/mg protein
• Assay: ≥80 μ protein/vial (BCA)
• Biological source: (Aplysia californica)
• Concentration: ≤10% (BCA method)

Properties

• biological source: (Aplysia californica)
• Quality Segment: 200
• assay: ≥80 μ protein/vial (BCA)
• form: lyophilized powder
• specific activity: 1000-3000 units/mg protein
• composition: Protein, ≤10%
• packaging: vial of ≥80 μg protein
• storage condition: dry at room temperature
• concentration: ≤10% (BCA method)
• suitability: suitable for enzyme test
• application(s): genomic analysis
• storage temp.: −20°C

Description

Application

ADP-ribosylcyclase is a Ca²⁺ signaling second messenger. It may be used to study calcium signaling and has been used to research morphine antinociception and tolerance [1].

Biochem/physiol Actions

ADP-ribosylcyclase is an intracellular calcium regulator that cyclizes NAD into cADPR. It is thought that the majority of ADP-ribosylcyclase activity in the brain is linked to CD38. Nicotinamide is a known inhibitor of CD38 ADP-ribosylcyclase activity [1].

Physical form

Lyophilized powder containing trehalose, potassium phosphate and dithiothreitol

Other Notes

One unit will produce 1 μmole of cyclic ADP ribose from β-NAD⁺ in 5 minutes at pH 7.0 and 25°C.

Safety Information

• pictograms: GHS08
• signalword: Danger
• hcodes: H334
• pcodes: P261 - P284 - P501
• Hazard Classifications: Resp. Sens. 1
• Storage Class: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)