A8106

Altanserin hydrochloride hydrate

≥98% (HPLC), solid

• Synonym(s): 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1H)-quinazolinone hydrochloride hydrate
• Empirical Formula (Hill Notation): C₂₂H₂₂FN₃O₂S · HCl · xH₂O
• CAS Number: 76330-71-7
• Molecular Weight: 447.95 (anhydrous basis)
• NACRES: NA.77
• PubChem Substance ID: 329770947
• UNSPSC Code: 12352200
• MDL number: MFCD11045280
• Assay: ≥98% (HPLC)
• Form: solid

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• solubility: DMSO: >5 mg/mL, H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: O.Cl.Fc1ccc(cc1)C(=O)C2CCN(CC2)CCN3C(=S)Nc4ccccc4C3=O
• InChI: 1S/C22H22FN3O2S.ClH.H2O/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29;;/h1-8,16H,9-14H2,(H,24,29);1H;1H2
• InChI key: MFGBKMPKRJCLPK-UHFFFAOYSA-N

Description

Application

Altanserin hydrochloride hydrate has been used in the pretreatment of rat brain samples and as a non-radioactive control in the calibration curve preparation for quantifying ^[18F]altanserin in high-performance liquid chromatography.[1]

Altanserin hydrochloride hydrate is a specific 5-HT₂/serotonergic antagonist and has been used in a study to assess serotonin release capacity in the human brain.

Biochem/physiol Actions

Altanserin hydrochloride hydrate is a specific 5-HT₂/serotonergic antagonist.

The radioligand of altanserin, ^[18F]altanserin is useful as a positron emission tomography (PET)-radioligand for the visualization and quantification of serotonin_2A (5-HT_2A) receptors.[2]

Safety Information

• pcodes: P264 - P280 - P305 + P351 + P338 - P337 + P313
• pictograms: GHS07
• signalword: Warning
• hcodes: H319
• Hazard Classifications: Eye Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves