This product is recommended to be soluble in water at 50 mg/ml. Aqueous solutions of ATP are stable for months when frozen at –15 °C, and for approximately one week at 0 °C.
A7699
Adenosine 5′-triphosphate disodium salt hydrate
BioXtra, ≥99% (HPLC), from microbial
Adenosine 5′-triphosphate disodium salt hydrate
Synonym(s):
ATP disodium salt
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1 G
CZK 7,220.00
5 G
CZK 20,400.00
10 G
CZK 42,200.00
About This Item
Empirical Formula (Hill Notation):
C10H14N5Na2O13P3 · xH2O
CAS Number:
Molecular Weight:
551.14 (anhydrous basis)
PubChem Substance ID:
eCl@ss:
32160414
UNSPSC Code:
41106305
NACRES:
NA.51
EC Number:
213-579-1
MDL number:
Form:
powder
Assay:
≥99% (HPLC)
Solubility:
H2O: 50 mg/mL, clear, colorless
Biological source:
microbial
Color:
white
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InChI key
NTBQNWBHIXNPRU-MSQVLRTGSA-L
InChI
1S/C10H16N5O13P3.2Na.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;;1H2/q;2*+1;/p-2/t4-,6-,7-,10-;;;/m1.../s1
SMILES string
O.[Na+].[Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O
biological source
microbial
product line
BioXtra
assay
≥99% (HPLC)
form
powder
Quality Level
mol wt
551.14 g/mol
impurities
≤0.1% inorganic P, ≤3% solvent content
color
white
pKa
(1) 4.0, (2) 6.5
solubility
H2O: 50 mg/mL, clear, colorless
anion traces
chloride (Cl-): ≤0.05%
cation traces
Al: ≤0.005%, Ca: ≤0.01%, Cu: ≤0.001%, Fe: ≤0.05%, K: ≤0.01%, Mg: ≤0.005%, NH4+: ≤0.05%, Pb: ≤0.001%, Zn: ≤0.0005%
λmax
259 nm
fluorescence
λem 15.4 in 0.1 M phosphate pH 7.0
storage temp.
−20°C
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1 of 4
This Item | |||
|---|---|---|---|
| assay ≥99% (HPLC) | assay ≥99% (HPLC) | assay 99% | assay ≥97% (HPLC) |
| solubility H2O: 50 mg/mL, clear, colorless | solubility H2O: 50 mg/mL | solubility - | solubility H2O: 50 mg/mL |
| Quality Level 300 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| biological source microbial | biological source microbial | biological source - | biological source microbial |
| storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. −20°C |
| form powder | form powder | form - | form crystalline |
Application
Adenosine 5γ-triphosphate (ATP) is a central component of energy storage and metabolism in vivo. ATP is use in many cellular processes, respiration, biosynthetic reactions, motility, and cell division. ATP is a substrate of many kinases involved in cell signaling and of adenylate cyclase(s) that produce the second messenger cAMP. ATP provides the metabolic energy to drive metabolic pumps. ATP serves as a coenzyme in a wide array of enzymatic reactions.
Biochem/physiol Actions
P2 purinergic agonist; increases activity of Ca2+-activated K+ channels; substrate for ATP-dependent enzyme systems
P2 purinocepter agonist.
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type N95 (US)
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Stefan P Mortensen et al.
The Journal of physiology, 589(Pt 7), 1847-1857 (2011-02-09)
Intraluminal ATP could play an important role in the local regulation of skeletal muscle blood flow, but the stimuli that cause ATP release and the levels of plasma ATP in vessels supplying and draining human skeletal muscle remain unclear. To
Mark W Gorman et al.
American journal of physiology. Heart and circulatory physiology, 299(6), H1981-H1989 (2010-09-21)
The adenine nucleotide hypothesis postulates that the ATP released from red blood cells is broken down to ADP and AMP in coronary capillaries and that ATP, ADP, and AMP act on purinergic receptors on the surface of capillary endothelial cells.
Shaima'a Hamarsheh et al.
Nature communications, 11(1), 1659-1659 (2020-04-05)
Oncogenic Ras mutations occur in various leukemias. It was unclear if, besides the direct transforming effect via constant RAS/MEK/ERK signaling, an inflammation-related effect of KRAS contributes to the disease. Here, we identify a functional link between oncogenic KrasG12D and NLRP3
Marc Clement et al.
Arteriosclerosis, thrombosis, and vascular biology, 39(8), 1645-1651 (2019-06-07)
MARK4 (microtubule affinity-regulating kinase 4) regulates NLRP3 (nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain containing 3) inflammasome activation. The aim of the study is to examine the role of MARK4 in hematopoietic cells during atherosclerosis. We show increased MARK4
Alexander Puzenko et al.
The Journal of chemical physics, 137(19), 194502-194502 (2012-11-28)
In this, the third part of our series on the dielectric spectrum symmetrical broadening of water, we consider the nucleotide aqueous solutions. Where in Parts I [E. Levy et al., J. Chem. Phys. 136, 114502 (2012)] and II [E. Levy
Protocols
HILIC separation is an alternative that permits sensitive MS detection and without the use of ion-pair reagents.
ZIC®-cHILIC is a densely bonded zwitterionic stationary phase with phosphorylcholine functional groups covalently attached to silica.
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Product Information Sheet
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Should I dilute ATP in distilled water for calcium flux imaging experiment in vitro (or HBSS/DMEM medium..) ? Moreover, ATP is stable at 0°C, but should I put the ATP in my 37°C medium at the same temperature or at 0°C ?
1 answer-
Helpful?
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What is the solubility of Product A7699, Adenosine 5´-triphosphate disodium salt hydrate (ATP)?
1 answer-
ATP disodium salt is soluble in water (50 mg/mL), yielding a clear, colorless solution. This solution is mildly acidic (pH approximately 3.5).
Helpful?
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Helpful?
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What is the stability of Product A7699, Adenosine 5´-triphosphate disodium salt hydrate (ATP), in solution?
1 answer-
Aqueous solutions of ATP are stable for months when frozen at -15°C and for approximately one week at 0°C. ADP is the first hydrolysis product formed, with additional hydrolysis leading to the formation of AMP. However, ATP solutions are only stable for several hours at 0 °C when dissolved in a trichloroacetic acid solution. In alkaline solution, it rapidly decomposes to inorganic pyrophosphate and adenosine 5'-phosphate even at 0 °C. This information can be found on the product information sheet (under Documents, above.
Helpful?
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What is the water content of Product A7699, Adenosine 5´-triphosphate disodium salt hydrate (ATP)? Does the formula weight listed on the website include water?
1 answer-
The formula weight on the website does not include water as the amount of water in the product will vary from lot to lot. The water content for any specific lot will be reported on the Certificate of Analysis for that lot.
Helpful?
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