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Amyloid β-Protein Fragment 17-40

Name: Amyloid β-Protein Fragment 17-40
Brand: SIGMA

≥87% (HPLC), lyophilized powder

About This Item

NACRES:

NA.77

PubChem Substance ID:

329770861

UNSPSC Code:

12352202

MDL number:

MFCD00671443

Form:

lyophilized powder

Assay:

≥87% (HPLC)

Mol wt:

2393

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Properties

assay

≥87% (HPLC)

form

lyophilized powder

mol wt

2393

composition

Peptide content, ≥75%

solubility

H₂O: soluble

UniProt accession no.

P05067

storage temp.

−20°C

SMILES string

CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(C)C)C(C)C)C(C)C)[C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(O)=O

InChI

1S/C110H178N26O31S/c1-22-61(17)90(106(162)118-51-80(141)121-71(43-55(5)6)99(155)125-70(39-41-168-21)97(153)132-85(56(7)8)104(160)116-48-78(139)114-49-82(143)130-87(58(11)12)108(164)134-89(60(15)16)110(166)167)136-109(165)91(62(18)23-2)135-93(149)63(19)119-79(140)50-115-95(151)68(36-30-31-40-111)124-101(157)74(46-77(113)138)127-103(159)76(53-137)122-81(142)52-117-105(161)86(57(9)10)133-102(158)75(47-84(146)147)128-96(152)69(37-38-83(144)145)123-92(148)64(20)120-98(154)72(44-65-32-26-24-27-33-65)126-100(156)73(45-66-34-28-25-29-35-66)129-107(163)88(59(13)14)131-94(150)67(112)42-54(3)4/h24-29,32-35,54-64,67-76,85-91,137H,22-23,30-31,36-53,111-112H2,1-21H3,(H2,113,138)(H,114,139)(H,115,151)(H,116,160)(H,117,161)(H,118,162)(H,119,140)(H,120,154)(H,121,141)(H,122,142)(H,123,148)(H,124,157)(H,125,155)(H,126,156)(H,127,159)(H,128,152)(H,129,163)(H,130,143)(H,131,150)(H,132,153)(H,133,158)(H,134,164)(H,135,149)(H,136,165)(H,144,145)(H,146,147)(H,166,167)/t61-,62-,63-,64-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,85-,86-,87-,88-,89-,90-,91-/m0/s1

InChI key

QKAFHCYMOBODRG-FZSVSODXSA-N

Gene Information

human ... APP(351)

Description

Application

Aβ fragment used to study aggregation.

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1 of 1

This Item	A7973	A2326	A2201
Sigma-Aldrich A4848 Amyloid β-Protein Fragment 17-40	Sigma-Aldrich A7973 [Arg¹³] Amyloid-β-Protein Fragment 1-40	Sigma-Aldrich A2326 Amyloid β-Protein Fragment 40-1	Sigma-Aldrich A2201 Amyloid β-Protein Fragment 35-25
assay ≥87% (HPLC)	assay ≥80% (HPLC)	assay ≥90% (HPLC)	assay ≥95% (HPLC)
form lyophilized powder	form lyophilized powder	form powder	form powder
mol wt 2393	mol wt 4350	mol wt -	mol wt -
UniProt accession no. P05067	UniProt accession no. P05067	UniProt accession no. P05067	UniProt accession no. P05067
Gene Information human ... APP(351)	Gene Information human ... APP(351)	Gene Information human ... APP(351)	Gene Information human ... APP(351)
solubility H₂O: soluble	solubility H₂O: soluble	solubility -	solubility -

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Secondary structure of amyloid beta peptide correlates with neurotoxic activity in vitro.

L K Simmons et al.

Molecular pharmacology, 45(3), 373-379 (1994-03-01)

Amyloid beta peptide (A beta), the major protein constituent of senile plaques in patients with Alzheimer's disease, is believed to facilitate the progressive neurodegeneration that occurs in the latter stages of this disease. Early attempts to characterize the structure-activity relationship

Global Trade Item Number

SKU	GTIN
A4848-.5MG	04061833416235

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