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A0779

p-Aminoclonidine hydrochloride

solid

Synonym(s):

2-(4-Amino-2,6-dichloroanilino)-2-imidazoline hydrochloride, Apraclonidine hydrochloride

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1 mg
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CZK 1,570.00
CZK 1,334.50

About This Item

Empirical Formula (Hill Notation):
C9H10Cl2N4 · xHCl
Molecular Weight:
245.11 (free base basis)
NACRES:
NA.77
PubChem Substance ID:
24277751
UNSPSC Code:
12352200
MDL number:
MFCD00135922
Form:
solid
Quality level:
100

CZK 1,334.50

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form

solid

Quality Level

100

color

white

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.4 mg/mL (Solutions may be stored for several days at 4 °C), boiling water: 100 mg/mL (Solutions may be stored for several days at 4 °C), 0.1 M HCl: soluble (Solutions may be stored for several days at 4 °C), methanol: soluble (Solutions may be stored for several days at 4 °C)

storage temp.

2-8°C

SMILES string

Cl[H].Nc1cc(Cl)c(NC2=NCCN2)c(Cl)c1

InChI

1S/C9H10Cl2N4.ClH/c10-6-3-5(12)4-7(11)8(6)15-9-13-1-2-14-9;/h3-4H,1-2,12H2,(H2,13,14,15);1H

InChI key

OTQYGBJVDRBCHC-UHFFFAOYSA-N

Gene Information

human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)

Biochem/physiol Actions

α2-adrenoceptor agonist.

Features and Benefits

This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item
C7897B016A1784
p-Aminoclonidine hydrochloride solid

Sigma-Aldrich

A0779

p-Aminoclonidine hydrochloride

Clonidine hydrochloride solid

Sigma-Aldrich

C7897

Clonidine hydrochloride

Benoxathian hydrochloride solid

Sigma-Aldrich

B016

Benoxathian hydrochloride

Aminopterin powder

Sigma-Aldrich

A1784

Aminopterin

form

solid

form

solid

form

solid

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

200

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

storage temp.

−20°C

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.4 mg/mL (Solutions may be stored for several days at 4 °C), 0.1 M HCl: soluble (Solutions may be stored for several days at 4 °C), methanol: soluble (Solutions may be stored for several days at 4 °C), boiling water: 100 mg/mL (Solutions may be stored for several days at 4 °C)

solubility

H2O: soluble, methanol: soluble

solubility

H2O: soluble (Aqueous solutions may be stored for several weeks at -20 °C.), ethanol: soluble, isopropanol: soluble

solubility

2 M NaOH: 50 mg/mL (Solutions may be stored for 1-2 days at 4°C.)

color

white

color

white

color

white

color

light yellow to yellow-brown

Gene Information

human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)

Gene Information

human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

Gene Information

human ... FPGS(2356)
mouse ... Fpgs(14287)

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
MKBZ4552V
SLBF8497V
SLBD9846V
081M1779V
120M1208V

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Articles

α2-Adrenoceptors

Learn about alpha-2 adrenoceptor and its subtypes, mediated responses, and applications of agonists. Included is a list of available products and a comparison table.

J Cepelík et al.
Physiological research, 46(3), 203-208 (1997-01-01)
The effects of the selective alpha2-adrenergic agonist p-aminoclonidine, the nonselective adrenergic agonist epinephrine, the selective beta2-adrenergic agonist fenoterol and the adenosine A1 agonist R-PIA on intraocular pressure were studied in control and pertussis toxin-pretreated rabbits. Pretreatment of rabbits with pertussis
T Salminen et al.
The Journal of biological chemistry, 274(33), 23405-23413 (1999-08-07)
We have compared bacteriorhodopsin-based (alpha(2A)-AR(BR)) and rhodopsin-based (alpha(2A)-AR(R)) models of the human alpha(2A)-adrenengic receptor (alpha(2A)-AR) using both docking simulations and experimental receptor alkylation studies with chloroethylclonidine and 2-aminoethyl methanethiosulfonate hydrobromide. The results indicate that the alpha(2A)-AR(R) model provides a better
M E Alburges et al.
Brain research bulletin, 32(2), 97-102 (1993-01-01)
The localization of alpha 2-receptors was determined by quantitative autoradiography using [125I]para-iodoclonidine ([125I]PIC) and [3H]para-aminoclonidine ([3H]PAC). In cortical tissue, [125I]PIC and [3H]PAC were equipotent in their capacity to bind sites recognized by oxymetazoline (preferentially binds to the alpha 2A receptor

Global Trade Item Number

SKUGTIN
A0779-5MG04061832268903
A0779-1MG04061825980430

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