A0430
1-Aminocyclopropanecarboxylic acid hydrochloride
≥98%
Synonym(s):
ACPC
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About This Item
Linear Formula:
H2NC3H4CO2H·HCl
CAS Number:
Molecular Weight:
137.56
UNSPSC Code:
12352209
PubChem Substance ID:
MDL number:
Assay:
≥98%
Form:
powder
assay
≥98%
form
powder
mp
231 °C (dec.) (lit.)
SMILES string
Cl.NC1(CC1)C(O)=O
InChI
1S/C4H7NO2.ClH/c5-4(1-2-4)3(6)7;/h1-2,5H2,(H,6,7);1H
InChI key
WTZRHZRMLYNBRM-UHFFFAOYSA-N
Gene Information
human ... GRIN1(2902), GRINA(2907)
Biochem/physiol Actions
1-Aminocyclopropanecarboxylic acid hydrochloride (ACPC) contains 3-membered carbocyclic rings and is a cyclic homolog of glycine. It acts as an agonist of the N-methyl-D-aspartate (NMDA) receptor.[1] It elicits protection against glutamate-induced neurotoxicity in neurons.[2]
NMDA glutamate receptor agonist acting at the glycine site
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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1-Aminocyclopropanecarboxylic acid, an antagonist of N-methyl-D-aspartate receptors, causes hypotensive and antioxidant effects with upregulation of heme oxygenase-1 in stroke-prone spontaneously hypertensive rats.
Gao, et al.
Hypertension Research, 30, 249-257 (2016)
Alan Anticevic et al.
Schizophrenia bulletin, 41(1), 133-143 (2014-05-02)
Bipolar illness is a debilitating neuropsychiatric disorder associated with alterations in the ventral anterior cingulate cortex (vACC), a brain region thought to regulate emotional behavior. Although recent data-driven functional connectivity studies provide evidence consistent with this possibility, the role of
Yunpeng Wang et al.
The international journal of neuropsychopharmacology, 20(7), 562-574 (2017-02-16)
Opiate addiction is associated with complex cognitive impairment, which contributes to the development of compulsive drug use and relapses. Dopamine and N-methyl-D-aspartate receptors play critical roles in opiate-induced cognitive deficits. However, the roles of D1 and D3 receptors in the