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A0384

Arcaine sulfate salt

Synonym(s):

1,4-Diguanidinobutane sulfate salt

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50 mg
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CZK 3,090.00

About This Item

Empirical Formula (Hill Notation):
C6H16N6 · H2O4S
CAS Number:
14923-17-2
Molecular Weight:
270.31
NACRES:
NA.77
PubChem Substance ID:
24277954
UNSPSC Code:
12352200
MDL number:
MFCD00050545
Assay:
≥98% (TLC)
Form:
powder
Quality level:
200

CZK 3,090.00

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biological source

synthetic (organic)

Quality Level

200

assay

≥98% (TLC)

form

powder

mp

>280 °C

solubility

1 M NaOH: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

SMILES string

OS(O)(=O)=O.NC(=N)NCCCCNC(N)=N

InChI

1S/C6H16N6.H2O4S/c7-5(8)11-3-1-2-4-12-6(9)10;1-5(2,3)4/h1-4H2,(H4,7,8,11)(H4,9,10,12);(H2,1,2,3,4)

InChI key

RWTGFMPOODRXIM-UHFFFAOYSA-N

Gene Information

human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRINA(2907)

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This Item
M7033A7127H7278
Arcaine sulfate salt

Sigma-Aldrich

A0384

Arcaine sulfate salt

NG-Methyl-L-arginine acetate salt ≥98% (TLC)

Sigma-Aldrich

M7033

NG-Methyl-L-arginine acetate salt

Agmatine sulfate salt ≥97%, powder

Sigma-Aldrich

A7127

Agmatine sulfate salt

NG-Hydroxy-L-arginine acetate salt

Sigma-Aldrich

H7278

NG-Hydroxy-L-arginine acetate salt

assay

≥98% (TLC)

assay

≥98% (TLC)

assay

≥97%

assay

≥98% (TLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

200

solubility

1 M NaOH: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

solubility

water: 49.00-51.00 mg/mL, clear to very slightly hazy, colorless to faintly yellow

solubility

H2O: 50 mg/mL, ethanol: insoluble

solubility

acetic acid: 10 mg/mL, clear, colorless to faintly yellow

biological source

synthetic (organic)

biological source

-

biological source

-

biological source

-

mp

>280 °C

mp

-

mp

234-238 °C (lit.)

mp

204 °C

Application

Arcaine sulfate salt has been used as an N-methyl-d-aspartate (NMDA) receptor effector/antagonist:
  • to evaluate its effects on the acquisition of electrical kindling of the amygdala[1]
  • to compare its effects with agmatine and MK801 on NMDA- or glutamate-induced neuronal damage[2]
  • to study its effects on cell-free translation of synthetic polynucleotide[3]

Biochem/physiol Actions

Arcaine sulfate salt (1,4-diguanidinobutane), a polyamine,[3] is an antagonist of the polyamine binding site of the N-methyl-d-aspartate (NMDA) receptor.[4] Arcaine, an agmatine analog,[2] along with ifenprodil, might have a possibility for therapeutic management in epileptic disorders.[1]

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
SLCL4063
SLCF8524
SLBT4233
SLBR2066V
SLBJ9045V

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Min-Ching Kuo et al.
The European journal of neuroscience, 27(7), 1731-1738 (2008-03-29)
Recent evidence indicates that the mature central visual system retains a higher degree of plasticity than traditionally assumed. However, little is known regarding the neuromodulatory factors that influence plasticity in the adult primary visual cortex (V1). We investigated the role
Nandkishor Ramdas Kotagale et al.
Behavioural brain research, 213(2), 161-174 (2010-05-11)
Agmatine [2-(4-aminobutyl)guanidine] is an endogenous amine proposed as a neurotransmitter/neuromodulator that binds to multiple target receptors in brain. Besides, many central and peripheral functions, agmatine have been implicated in the process of drug addiction. The purpose of the present study
Ana Paula Chiapinotto Ceretta et al.
Psychopharmacology, 201(3), 405-411 (2008-09-02)
The polyamines putrescine, spermidine, and spermine are a group of aliphatic amines that may act as physiological modulators of the N-methyl-D-aspartate (NMDA) receptor, a glutamate receptor implicated in memory formation and consolidation. Arcaine is a competitive antagonist of the polyamine
Wei-Ping Wang et al.
Brain research, 1084(1), 210-216 (2006-03-21)
Agmatine is a polyamine and has been considered as a novel neurotransmitter or neuromodulator in the central nervous system. In the present study, the neuroprotective effect of agmatine against cell damage caused by N-methyl-D-aspartate (NMDA) and glutamate was investigated in
Maribel A Rubin et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 24(9), 2328-2334 (2004-03-06)
Amygdalar NMDA receptor activation has been implicated in the acquisition of fear memories in rats. However, little is known about the role of endogenous modulators of the NMDA receptor, such as polyamines, in pavlovian fear-conditioning learning. Therefore, in the present
View All Related Papers

Global Trade Item Number

SKUGTIN
A0384-50MG04061832088501

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