227R-2

BCL6 (EP278) Rabbit Monoclonal Primary Antibody

• NACRES: NA.41
• UNSPSC Code: 12352203
• Conjugate: unconjugated
• Clone: EP278, monoclonal
• Application: IHC (p)
• Citations: 11

Properties

• biological source: rabbit
• Quality Level: 100, 500
• conjugate: unconjugated
• antibody form: culture supernatant
• antibody product type: primary antibodies
• clone: EP278, monoclonal
• description: (For In Vitro Diagnostic Use in Select Regions (See Chart))
• form: buffered aqueous solution
• species reactivity: human
• packaging: bottle of 1.0 mL predilute (227R-27), bottle of 7.0 mL predilute (227R-28), vial of 0.1 mL concentrate (227R-24), vial of 0.5 mL concentrate (227R-25), vial of 1.0 mL concentrate (227R-26), vial of 0.1 mL concentrate Research Use Only (227R-24-RUO), vial of 1.0 mL concentrate Research Use Only (227R-26-RUO), vial of 1.0 mL pre-dilute Research Use Only (227R-27-RUO), vial of 7.0 mL pre-dilute ready-to-use Research Use Only (227R-28-RUO)
• manufacturer/tradename: Cell Marque^®
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
• isotype: IgG
• control: tonsil
• shipped in: wet ice
• storage temp.: 2-8°C
• visualization: nuclear
• Gene Information: human ... BCL6(604)

Description

General description

BCL6 is a transcriptional regulator gene which codes for a 706-amino-acid nuclear zinc finger protein.¹ In normal tissue these antibodies have strong nuclear staining for a subset of B-lymphocytes, mostly located in germinal centers (GC).² BCL6 antibodies stain malignant cells in follicular lymphoma,³ diffuse large B-cell lymphomas,⁴ Burkitt lymphoma,⁴ classical Hodgkin lymphoma,⁵ as well as majority of tumor cells in nodular lymphocyte predominant Hodgkin lymphoma.⁶ BCL6 expression has been also seen in anaplastic large cell lymphomas (ALCL).⁷

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Analysis Note

IVD

IVD

IVD

RUO

Other Notes

BCL6 Positive Control Slides, Product No. 227S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

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Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable