18887
Byzen Pro™ Protein A resin
suitable for affinity chromatography
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About This Item
NACRES:
NA.56
UNSPSC Code:
13111000
Form:
suspension
To inquire about this product 18887, please contact your local Merck office or dealer. Contact Technical Service
form
suspension
technique(s)
affinity chromatography: suitable
mean particle size
70 μm
storage temp.
2-8°C
Application
Byzen Pro™ Protein A resin is an affinity chromatography medium in which a novel Protein A mutant is used as a ligand. Conventional protein A resins use strongly acidic buffers to elute antibodies, exposing the target antibody to the risks of aggregation and decreased activities. In contrast, this temperature- responding Byzen Pro™ Protein A resin allows antibodies to be eluted under neutral pH by a simple temperature change. This eliminates any risk of aggregation and decreased activity of the antibody, improving manufacturing efficiency for pharmaceutical antibodies.
Features and Benefits
Typical Product Profile:
Bead Structure, Cross-linked polyvinyl alcohol, Mean Particle Size 70 μm, Max. Back Pressure 0.3 MPa, Flow Rate (Recommended) 125-250 cm/h, pH Range (Recommended) pH 6-8, Ligand: Recombinant Protein A mutant, Ligand Immobilization: Multiple ligation, Dynamic Binding Capacity (20 cm column): 26 g/L (250 cm/h) 34 g/L (125 cm/h), Total Binding Capacity 40 g/L, Binding Temperature Below 10°C, Eluting Temperature 37 to 40°C, Mode of Temperature Change: Conventional heat exchange system can be used.
Bead Structure, Cross-linked polyvinyl alcohol, Mean Particle Size 70 μm, Max. Back Pressure 0.3 MPa, Flow Rate (Recommended) 125-250 cm/h, pH Range (Recommended) pH 6-8, Ligand: Recombinant Protein A mutant, Ligand Immobilization: Multiple ligation, Dynamic Binding Capacity (20 cm column): 26 g/L (250 cm/h) 34 g/L (125 cm/h), Total Binding Capacity 40 g/L, Binding Temperature Below 10°C, Eluting Temperature 37 to 40°C, Mode of Temperature Change: Conventional heat exchange system can be used.
Legal Information
Byzen Pro is a trademark of Nomadic Bioscience Co., Ltd
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This Item | |||
|---|---|---|---|
| technique(s) affinity chromatography: suitable | technique(s) affinity chromatography: suitable | technique(s) - | technique(s) affinity chromatography: suitable |
| form suspension | form saline suspension | form aqueous suspension | form lyophilized powder |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| mean particle size 70 μm | mean particle size - | mean particle size - | mean particle size - |
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Related Content
Manual for Antibody Purification by Affinity Chromatography using 18887 Byzen ProTM Protein A resin
Ichiro Koguma et al.
Journal of chromatography. A, 1305, 149-153 (2013-07-31)
We attempted to evaluate a novel purification method of immunoglobulins (IgGs) by using a mutant type of protein A. Although this mutant protein A binds to IgGs at 5°C, the IgGs are released at 40°C; hence, it was designated as
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 532134-25G | 04061831820812 |
| 18887-5ML | 04061838212191 |
| 18887-1ML | 04061838089939 |
| 18887-25ML | 04061838083944 |
| 18887-2ML | 04061836971038 |