BP802

Lamivudine

British Pharmacopoeia (BP) Reference Standard

• Synonym(s): 2′,3′-Dideoxy-3′-thiacytidine, 3TC, Epivir, Epivir-HBV, Heptovir, Zeffix
• Empirical Formula (Hill Notation): C₈H₁₁N₃O₃S
• CAS Number: 134678-17-4
• Molecular Weight: 229.26
• UNSPSC Code: 41116107
• NACRES: NA.24
• MDL number: MFCD00869739

Properties

• grade: pharmaceutical primary standard
• API family: lamivudine
• form: solid
• shelf life: limited shelf life, expiry date on the label
• manufacturer/tradename: BP
• application(s): pharmaceutical; pharmaceutical small molecule
• format: neat
• storage temp.: 2-8°C
• SMILES string: NC1=NC(=O)N(C=C1)[C@@H]2CS[C@H](CO)O2
• InChI: 1S/C8H11N3O3S/c9-5-1-2-11(8(13)10-5)6-4-15-7(3-12)14-6/h1-2,6-7,12H,3-4H2,(H2,9,10,13)/t6-,7+/m0/s1
• InChI key: JTEGQNOMFQHVDC-NKWVEPMBSA-N

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Lamivudine BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:

Abacavir, Zidovudine and Lamivudine Tablets

Zidovudine and Lamivudine Tablets

Abacavir and Lamivudine Tablets

Lamivudine Tablets

Biochem/physiol Actions

Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor (nRTI).

Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor (nRTI). It is an analogue of cytidine, and can inhibit both types (1 and 2) of HIV reverse transcriptase as well as the reverse transcriptase of hepatitis B. It needs to be phosphorylated to its triphosphate form before it is active. 3TC-triphosphate also inhibits cellular DNA polymerase.

Packaging

Unit quantity: 200 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

Other Notes

Sales restrictions may apply.

Safety Information

• pictograms: GHS08
• signalword: Warning
• Storage Class: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• target_organs: Blood
• hcodes: H361d,H373,H412
• pcodes: P202 - P260 - P273 - P280 - P308 + P313 - P405
• Hazard Classifications: Aquatic Chronic 3 - Repr. 2 - STOT RE 2