B5899
Buflomedil hydrochloride
analytical standard
Synonym(s):
4-(1-Pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone
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About This Item
Empirical Formula (Hill Notation):
C17H25NO4 · HCl
CAS Number:
Molecular Weight:
343.85
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
252-611-9
MDL number:
grade
analytical standard
Quality Segment
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
veterinary
format
neat
SMILES string
Cl.COc1cc(OC)c(C(=O)CCCN2CCCC2)c(OC)c1
InChI
1S/C17H25NO4.ClH/c1-20-13-11-15(21-2)17(16(12-13)22-3)14(19)7-6-10-18-8-4-5-9-18;/h11-12H,4-10H2,1-3H3;1H
InChI key
ZDPACSAHMZADFZ-UHFFFAOYSA-N
Gene Information
human ... EBP(10682)
General description
Buflomedil hydrochloride is a vasoactive agent. Its mode of action involves increasing the peripheral and cerebral blood flow in ischaemic tissues of patients, who are mostly affected with vascular diseases.
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Buflomedil hydrochloride may be used as an analytical standard for the determination of buflomedil in biological matrices using high-performance liquid chromatography technique. It may also be used as an analytical reference standard for the quantification of the analyte in pharmaceutical formulations and serum samples using electroanalytical and chromatographic techniques.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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D Tsantilas et al.
International angiology : a journal of the International Union of Angiology, 30(2), 164-171 (2011-03-24)
The aim of this study was to assess the effects of buflomedil on the peripheral microcirculation in patients with type 2 diabetes mellitus (T2DM) without overt micro- or macroangiopathy. Twenty-three patients with T2DM were randomly assigned to receive buflomedil 600
Tine L M de Backer et al.
The Cochrane database of systematic reviews, 3(3), CD000988-CD000988 (2013-04-02)
Intermittent claudication (IC) is pain caused by chronic occlusive arterial disease, that develops in a limb during exercise and is relieved with rest. Buflomedil is a vasoactive agent used to treat peripheral vascular disease. However, its clinical efficacy for IC
F Mallard et al.
Chirurgie de la main, 31(6), 358-363 (2012-11-28)
Digital tourniquet is a quick, simple and reliable method to ensure a bloodless operative field distal to the MP joint. However, a forgotten tourniquet is an exceptional but serious complication related to digital ischemia. Few cases were reported in literature