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Anti-CHIP/STUB1 Antibody

Name: Anti-CHIP/STUB1 Antibody
Brand: MM

Chemicon^®, from goat

Synonym(s):

CHIP, STUB1

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ELISA, WB

Citations:

This product is discontinued. Contact Technical Servicefor assistance.

Properties

biological source

goat

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human, chimpanzee

manufacturer/tradename

Chemicon^®

technique(s)

ELISA: suitable, western blot: suitable

NCBI accession no.

NM_005861.2

UniProt accession no.

Q9UNE7

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... STUB1(10273)

Description

General description

U box domain E3 ubiquitin ligase. CHIP E3 controls both the association of Hsp70/Hsp90 chaperones with ErbB2 and the down-regulation of ErbB2 induced by inhibitors of Hsp90. CHIP-induced degradation was observed for mutant and wild-type p53, which transiently associate with molecular chaperones Hsc70 and Hsp90 and can be diverted onto a degradation pathway through this association. Also, CHIP can interact with the Smad1/Smad4 proteins and block BMP signal transduction through the ubiquitin-mediated degradation of Smad proteins.

Immunogen

Peptide with sequence DAFISENGWVEDY, from the C-terminus of the protein sequence according to NP_005852.

Application

This Anti-CHIP/STUB1 Antibody is validated for use in ELISA, WB for the detection of CHIP/STUB1.

Physical form

Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Analysis Note

Control
Positive Control: Highly expressed in brain, heart, skelatal muscle, pancreas and placenta. Weak expression in kidney, liver and lung.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Compare Similar Items

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Show Differences

1 of 1

This Item	SAB2501000	SAB2103799	HPA041222
Sigma-Aldrich AB10000 Anti-CHIP/STUB1 Antibody	Sigma-Aldrich SAB2501000 Anti-STUB1/CHIP antibody produced in goat	Sigma-Aldrich SAB2103799 Anti-STUB1, (N-terminal) antibody produced in rabbit	Sigma-Aldrich HPA041222 Anti-STUB1 antibody produced in rabbit
Quality Level 100	Quality Level -	Quality Level -	Quality Level 100
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
biological source goat	biological source goat	biological source rabbit	biological source rabbit
UniProt accession no. Q9UNE7	UniProt accession no. Q9UNE7	UniProt accession no. Q9UNE7	UniProt accession no. Q9UNE7
species reactivity human, chimpanzee	species reactivity mouse, rat, human, canine, bovine	species reactivity bovine, mouse, guinea pig, rat, human	species reactivity human

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Chemical Regulation of the Protein Quality Control E3 Ubiquitin Ligase C-Terminus of Hsc70 Interacting Protein (CHIP).

Adam J Kanack et al.

Chembiochem : a European journal of chemical biology, 23(6), e202100633-e202100633 (2022-01-22)

The ubiquitin ligase C-terminus of Hsc70 interacting protein (CHIP) is an important regulator of proteostasis. Despite playing an important role in maintaining proteostasis, little progress has been made in developing small molecules that regulate ubiquitin transfer by CHIP. Here we

Most mutations that cause spinocerebellar ataxia autosomal recessive type 16 (SCAR16) destabilize the protein quality-control E3 ligase CHIP.

Adam J Kanack et al.

The Journal of biological chemistry, 293(8), 2735-2743 (2018-01-11)

The accumulation of misfolded proteins promotes protein aggregation and neuronal death in many neurodegenerative diseases. To counteract misfolded protein accumulation, neurons have pathways that recognize and refold or degrade aggregation-prone proteins. One U-box-containing E3 ligase, C terminus of Hsc70-interacting protein

Carboxyl terminus of Hsp70-interacting protein (CHIP) is required to modulate cardiac hypertrophy and attenuate autophagy during exercise.

Monte S Willis et al.

Cell biochemistry and function, 31(8), 724-735 (2013-04-05)

The carboxyl terminus of Hsp70-interacting protein (CHIP) is a ubiquitin ligase/cochaperone critical for the maintenance of cardiac function. Mice lacking CHIP (CHIP-/-) suffer decreased survival, enhanced myocardial injury and increased arrhythmias compared with wild-type controls following challenge with cardiac ischaemia