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8.55116

Methyl Indole AM resin

Novabiochem®

Synonym(s):

AM Methylindole Resin

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About This Item

NACRES:
NA.22
UNSPSC Code:
12352005
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Quality Segment

300

product line

Novabiochem®

form

beads

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

storage temp.

2-8°C

General description

[3-((Methyl-Fmoc-amino)-methyl)indol-1-yl] acetyl AM resin is an extremely useful support for the production of N-methyl substituted carboxamides and sulfonamides, as well as peptide N-methylamides [1]. After first removing the Fmoc group, loading of the resin with Fmoc-amino acids can be effected using HATU/DIPEA. Cleavage with TFA directly provides the product N-methylamide.

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins


Literature references

[1] K. G. Estep, et al. (1998) J. Org. Chem., 63, 5300.

Analysis Note

Colour (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.60 - 1.00 mmol/g
Swelling Volume (in CH₂Cl₂): lot specific result
The polymer matrix is copoly (styrene-1 % DVB), 100 - 200 mesh.

Other Notes

Replaces: 01-64-0451

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

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reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

product line

Novabiochem®

product line

Novabiochem®

product line

Novabiochem®

product line

Novabiochem®

Quality Level

300

Quality Level

200

Quality Level

200

Quality Level

200

application(s)

peptide synthesis

application(s)

peptide synthesis

application(s)

peptide synthesis

application(s)

peptide synthesis

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-30°C

storage temp.

2-8°C

form

beads

form

beads

form

beads

form

beads

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Protocols

Protokoly pro nakládání peptidové pryskyřice

Přehled různých pryskyřic, jako jsou Merrifieldova pryskyřice, pryskyřice na bázi tritylu a pryskyřice s hydroxymethylovou funkcí pro imobilizaci peptidů pro různé aplikace.

Peptide Resin Loading Protocols

Review various resins like Merrifield, trityl-based, and hydroxymethyl-functionalized for peptide immobilization for diverse applications.

Articles

Fmoc SPPS Linkers

Novabiochem® offers a wide range of linkers and derivatized resins for Fmoc solid-phase peptide synthesis with specialized protocols.

Global Trade Item Number

SKUGTIN
855116002504027269114589
855116000104027269114565
855116000504027269114572

Questions

  1. Will TFA treatment of peptides synthesized on the Methyl Indole AM resin result in peptides with methyl amide c-terminals?

    1 answer

    1. This resin is an extremely useful support for the production of N-methyl substituted carboxamides and sulfonamides, as well as peptide N-methylamides.

      After first removing the Fmoc group with piperidine, loading of the resin with Fmoc-amino acids can be effected using HATU/DIPEA. Cleavage with TFA directly provides the product N-methylamide. Please refer to method 4 for more information on a loading protocol for attachment of carboxylic acids to amino resins and method 2 for more information on general TFA cleavage.

      Method 4 : https://www.sigmaaldrich.com/technical-documents/technical-article/chemistry-and-synthesis/peptide-synthesis/peptide-resin-loading#Method4

      Method 2 : https://www.sigmaaldrich.com/technical-documents/technical-article/chemistry-and-synthesis/peptide-synthesis/fmoc-cleavage-deprotection#Method2

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