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For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf
8.00907
N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride
for peptide synthesis
Synonym(s):
N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride
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About This Item
Recommended Products
Product Name
N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride, for synthesis
Quality Level
form
solid
reaction suitability
reaction type: Coupling Reactions
mp
110-115 °C
application(s)
peptide synthesis
storage temp.
−20°C (−15°C to −25°C)
SMILES string
Cl.N(CCCN(CC)C#N)(C)C
InChI
1S/C8H17N3.ClH/c1-4-11(8-9)7-5-6-10(2)3;/h4-7H2,1-3H3;1H
InChI key
FDXPUDRRFDHONO-UHFFFAOYSA-N
General description
Application
- A water-soluble carbodiimide to facilitate peptide coupling reactions in alcohols.[1]
- A coupling agent along with HOBt to synthesize poly(glutamic acid) (PGA) polypeptides for the creation of non-fouling polypeptides that could be useful in a variety of biomedical applications.[2]
- A coupling reagent for the efficient synthesis of teriflunomide at the industrial scale.[3]
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 Oral
Storage Class Code
6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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How can I determine the shelf life / expiration / retest date of this product?
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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The packaging instructions recommend storing the item under an inert gas, but the safety data sheet does not specify this requirement. Would it suffice to store it in a refrigerator at -20°C instead?
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The recommended long term storage of this item is -15°C to -25°C. Clearing the headspace of the vial with argon before resealing is recommended. The stability of the product when stored otherwise cannot be guaranteed.
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