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662015

U 18666A

≥95% (HPLC), lyophilized solid, δ8-sterol isomerase inhibitor, Calbiochem®

Synonym(s):

U18666A, 3β-(2-Diethylaminoethoxy)androst-5-en-17-one, HCl

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10 mg

Available to ship TODAYfromAreál Kühne+Nagel spol. s r.o.

CZK 4,270.00

About This Item

Empirical Formula (Hill Notation):
C25H41NO2 · xHCl
CAS Number:
3039-71-2
Molecular Weight:
387.60 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00210908
Assay:
≥95% (HPLC)
Form:
lyophilized solid
Quality level:
100
Storage condition:
OK to freeze, desiccated (hygroscopic)

CZK 4,270.00

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Product Name

U18666A, A cell-permeable, amphiphilic amino-steroid that alters intracellular membrane protein trafficking by impairing intracellular biosynthesis and transport of LDL-derived cholesterol.

Quality Level

100

assay

≥95% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic)

color

white

solubility

water: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[Cl-].N(CCOC1CC2(C3C(C4C(CC3)(C(=O)CC4)C)CC=C2CC1)C)(CC)CC.[H+]

InChI

1S/C25H41NO2.ClH/c1-5-26(6-2)15-16-28-19-9-7-18-8-10-20-21-11-12-23(27)24(21,3)14-13-22(20)25(18,4)17-19;/h8,19-22H,5-7,9-17H2,1-4H3;1H

InChI key

ICPRVJHNLABCSA-UHFFFAOYSA-N

General description

A cell-permeable, amphiphilic amino-steroid that alters intracelluar membrane protein trafficking by impairing intracellular biosynthesis and transport of LDL-derived cholesterol. Reported to exert its effects via the inhibition of 2,3-oxidosqualene-lanosterol cyclase activity. Also reported to inhibit the activity of Δ8-sterol isomerase.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Activity of δ8-sterol isomerase
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Hall, A.M., et al. 2003. Pigment Cell Res.16, 149.
Kobayashi, T., et al. 1998. Nature392, 193.
Liscum, L. and Faust, J.R., 1989. J. Biol. Chem.264, 11796.
Sexton, R.C., et al. 1983. Biochemistry22, 5687.
Bierkamper, G.G. and Cenedella, R.J., 1978. Brain Res.150, 343.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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This Item
U3633190080124020
U18666A A cell-permeable, amphiphilic amino-steroid that alters intracellular membrane protein trafficking by impairing intracellular biosynthesis and transport of LDL-derived cholesterol.

Sigma-Aldrich

662015

U18666A

U 18666A powder

Sigma-Aldrich

U3633

U 18666A

AY 9944 A cell-permeable amphiphilic diamine that blocks cholesterol biosynthesis and its esterification.

Sigma-Aldrich

190080

AY 9944

Akt Inhibitor X The Akt Inhibitor X, also referenced under CAS 925681-41-0, controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

124020

Akt Inhibitor X

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

form

lyophilized solid

form

powder

form

solid

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

OK to freeze, desiccated (hygroscopic)

storage condition

-

storage condition

OK to freeze, desiccated (hygroscopic)

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Global Trade Item Number

SKUGTIN
662015-10MG04055977261042

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