539749

PTP1B Inhibitor

InSolution, ≥97%

• Synonym(s): PTP Inhibitor XXII, InSolution PTP1B Inhibitor
• Empirical Formula (Hill Notation): C₂₆H₁₉Br₂N₃O₇S₃
• Molecular Weight: 741.45
• NACRES: NA.77
• UNSPSC Code: 12352200
• Assay: ≥97% (HPLC)
• Form: liquid
• Storage condition: OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light

Properties

• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: liquid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light
• shipped in: ambient
• storage temp.: −20°C

Description

General description

A cell-permeable, selective, reversible, and non-competitive allosteric inhibitor of PTP1B (IC₅₀ = 4 µM and 8 µM for PTP1B₄₀₃ and PTP1B₂₉₈, respectively). Binds to a novel site away from the catalytic pocket and inhibits PTP1B activity by preventing closure of the WPD loop.

Biochem/physiol Actions

Cell permeable: yes

IC50 = 4 and 8 µM for PTP1B403 and PTP1B298, respectively

Reversible: yes

Packaging

Packaged under inert gas

Physical form

A 10 mM (2 mg/270 µl) solution of PTP1B Inhibitor (Cat. No. 539741) in DMSO.

Preparation Note

Following initial thaw, aliquot and freeze (-20°C).

Other Notes

Wiesmann, C., et al. 2004. Nat. Struct. Mol. Biol.11, 730.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk: WGK 1
• flash_point_f: 188.6 °F - closed cup - (Dimethylsulfoxide)
• flash_point_c: 87 °C - closed cup - (Dimethylsulfoxide)