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444249

MMP-2/MMP-9 Inhibitor II

The MMP-2/MMP-9 Inhibitor II, also referenced under CAS 193807-60-2, controls the biological activity of MMP-2/MMP-9. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Synonym(s):

MMP-2/MMP-9 Inhibitor II, (2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide, BiPS, BiPS

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Size/SKUAvailabilityPrice
1 mg

Available to ship TODAYfromAreál Kühne+Nagel spol. s r.o.

CZK 4,990.00
CZK 4,241.50

About This Item

Empirical Formula (Hill Notation):
C21H20N2O4S
CAS Number:
193807-60-2
Molecular Weight:
396.46
MDL number:
MFCD00008200
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze

CZK 4,241.50

List PriceCZK 4,990.00Save 15%

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Quality Segment

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

off-white

solubility

DMSO: 100 mg/mL, methanol: 25 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

A potent inhibitor of MMP-2 (IC50 = 17 nM) and MMP-9 (IC50 = 30 nM). Also shown to potently induce and rapidly activate HIF. Reported to inhibit Lewis lung carcinoma-induced lung colonization in a murine model.
A potent inhibitor of type IV collagenases, MMP-2 (IC50 = 17 nM) and MMP-9 (IC50 = 30 nM). Also shown to potently induce and rapidly activate HIF. Has been shown in vivo to inhibit Lewis lung carcinoma-induced lung colonization in a murine model.

Biochem/physiol Actions

Cell permeable: no
Primary Target
MMP-2
Product does not compete with ATP.
Reversible: no
Target IC50: 17 nM, 30 nM against MMP-2, and MMP-9, respectively

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Lauzier, M.C., et al. 2008. Mol. Pharmacol.In press.
Mifune, M., et al. 2005. J. Biol. Chem.280, 26592.
Zhang, H., et al. 2004. Circ. Res.95, 989.
Tamura, Y., et al. 1998. J. Med. Chem.41, 640.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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MMP-2/MMP-9 Inhibitor II The MMP-2/MMP-9 Inhibitor II, also referenced under CAS 193807-60-2, controls the biological activity of MMP-2/MMP-9. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Sigma-Aldrich

444249

MMP-2/MMP-9 Inhibitor II

MMP-9/MMP-13 Inhibitor I The MMP-9/MMP-13 Inhibitor I, also referenced under CAS 204140-01-2, controls the biological activity of MMP-9/MMP-13. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Millipore

444252

MMP-9/MMP-13 Inhibitor I

MMP-2/MMP-9 Inhibitor I The MMP-2/MMP-9 Inhibitor I, also referenced under CAS 193807-58-8, controls the biological activity of MMP-2/MMP-9. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Sigma-Aldrich

444241

MMP-2/MMP-9 Inhibitor I

MMP-3 Inhibitor II The MMP-3 Inhibitor II, also referenced under CAS 161314-17-6, controls the biological activity of MMP-3. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Sigma-Aldrich

444225

MMP-3 Inhibitor II

form

solid

form

solid

form

solid

form

solid

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (TLC)

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

10-30°C

solubility

DMSO: 100 mg/mL, methanol: 25 mg/mL

solubility

methanol: 1 mg/mL, DMSO: 100 mg/mL

solubility

DMSO: 200 mg/mL

solubility

DMSO: 30 mg/mL, ethanol: 8 mg/mL

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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