370660

Guanosine 3′,5′-cyclic Monophosphate, N²,2′-O-Dibutyryl-, Sodium Salt

Cell-permeable cGMP analog that preferentially activates protein kinase G.

• Synonym(s): Guanosine 3′,5′-cyclic Monophosphate, N²,2′-O-Dibutyryl-, Sodium Salt, Dibutyryl-cGMP, Na
• Empirical Formula (Hill Notation): C₁₈H₂₃N₅O₉P · Na
• CAS Number: 51116-00-8
• Molecular Weight: 507.37
• MDL number: MFCD00038422
• UNSPSC Code: 41106305
• NACRES: NA.77
• Assay: ≥95% (HPLC)
• Form: solid
• Quality level: 100
• Storage condition: OK to freeze, desiccated (hygroscopic)

Properties

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic)
• color: white
• solubility: ethanol: soluble, water: soluble
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: [Na+].[P]1(=O)(O[C@@H]2[C@H](O[C@H]([C@@H]2OC(=O)CCC)[n]3c4nc(nc(c4nc3)O)NC(=O)CCC)CO1)[O-]
• InChI: 1S/C18H24N5O9P.Na/c1-3-5-10(24)20-18-21-15-12(16(26)22-18)19-8-23(15)17-14(31-11(25)6-4-2)13-9(30-17)7-29-33(27,28)32-13;/h8-9,13-14,17H,3-7H2,1-2H3,(H,27,28)(H2,20,21,22,24,26);/q;+1/p-1/t9-,13-,14-,17-;/m1./s1
• InChI key: MGBPJXVWDGGLKI-GBIKJYCISA-M

Description

General description

Cell-permeable cGMP analog that preferentially activates protein kinase G. Inhibits thrombin stimulated arachidonic acid release in human platelets.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Cell-permeable cGMP analog that preferentially activates protein kinase G.

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Sane, D.C., et al. 1989. Biochem. Biophys. Res. Commun.165, 708.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable