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344827

Fucosyltransferase Inhibitor, 2F-Peracetyl-Fucose

2F-Peracetyl-Fucose is a cell-permeable fluorinated fucose derivative that acts as an inhibitor of fucosyltransferases following its uptake and metabolic transformation into a GDP-fucose mimetic.

Synonym(s):

Fucosyltransferase Inhibitor, 2F-Peracetyl-Fucose, (3S,4R,5R,6S)-3-fluoro-6-methyltetrahydro-2H-pyran-2,4,5-triyl triacetate

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Pack SizeSKUAvailabilityPrice
10 mg

Estimated to ship TODAYfromAreál Kühne+Nagel spol. s r.o.

CZK 8,780.00

About This Item

Empirical Formula (Hill Notation):
C12H17FO7
Molecular Weight:
292.26
NACRES:
NA.77
UNSPSC Code:
12352111
Assay:
≥98% (NMR)
Form:
solid
Quality level:
300
Storage condition:
OK to freeze, protect from light

CZK 8,780.00

Estimated to ship TODAYDetails

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Quality Level

300

assay

≥98% (NMR)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

−20°C

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Fucosyltransferase Inhibitor, 2F-Peracetyl-Fucose 2F-Peracetyl-Fucose is a cell-permeable fluorinated fucose derivative that acts as an inhibitor of fucosyltransferases following its uptake and metabolic transformation into a GDP-fucose mimetic.

Sigma-Aldrich

344827

Fucosyltransferase Inhibitor, 2F-Peracetyl-Fucose

Wnt Pathway Inhibitor XI, CCT036477 The Wnt Pathway Inhibitor XI, CCT036477, also referenced under CAS 305372-78-5, controls the biological activity of Wnt Pathway. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

681674

Wnt Pathway Inhibitor XI, CCT036477

STAT3 Inhibitor XVI The STAT3 Inhibitor XVI controls the biological activity of STAT3. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

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Glucose Transporter Inhibitor III, STF-31 The Glucose Transporter Inhibitor III, STF-31 controls the biological activity of Glucose Transporter.

Sigma-Aldrich

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form

solid

form

solid

form

solid

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

assay

≥98% (NMR)

assay

≥95% (1H-NMR)

assay

≥98% (HPLC)

assay

≥99% (HPLC)

Quality Level

300

Quality Level

100

Quality Level

100

Quality Level

100

solubility

DMSO: 10 mg/mL

solubility

DMSO: 50 mg/mL

solubility

DMSO: 50 mg/mL, light pink-purple

solubility

DMSO: 50 mg/mL

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

General description

A cell-permeable fluorinated fucose derivative that acts as an inhibitor of fucosyltransferases following its uptake and metabolic transformation into a GDP-fucose mimetic. Treatment of HL-60 cells with this inhibitor shows complete abolition of Lewis-X and SLex within 3 days. Also abolishes P-selectin binding and exhibits faster rolling cells on E-selectin and P-selectin coated surfaces. Does not affect cell viability or their doubling time even at 200 µM levels.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Fucosyltransferase
Reversible: yes

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Rillahan, C., et al. 2012.. Nat. Chem. Bio.8, 661.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Global Trade Item Number

SKUGTIN
344827-10MG04055977214833

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