324801

Epoxomicin

≥95% (HPLC), liquid, proteasome inhibitor, Calbiochem^®

• Synonym(s): InSolution Epoxomicin, Synthetic, Proteasome Inhibitor XIV
• Empirical Formula (Hill Notation): C₂₈H₅₀N₄O₇
• Molecular Weight: 554.72
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥95% (HPLC)
• Form: liquid
• Storage condition: OK to freeze, desiccated (hygroscopic), protect from light

Properties

• Product Name: Epoxomicin, InSolution, ≥95%
• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: liquid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic), protect from light
• shipped in: wet ice
• storage temp.: −20°C

Description

General description

Cell permeable: No


Product does not compete with ATP.


Reversible: No

Epoxomicin is a highly effective and selective proteasome inhibitor thatexhibits significant anti-inflammatory properties in vivo. This potent antitumor agent specifically targets the proteasome. Epoxomicin exhibits a stronger inhibitory effect on chymotrypsin-like activity compared to lactacystin and the peptide vinyl sulfone (NLVS). This powerful natural producteffectively inhibits nuclear factor kappa B (NF-κB) activation in vitro and signific antly reduces inflammation in the murine ear edema assay. Epoxomicin prevents the degradation of IκB and inhibits the activation of NF-κBDNA-binding activity. It can stabilize p53 levels in cell culture. It is an irreversible inhibitor of chymotrypsin-like (CT-L), trypsin-like (T-L), and peptidylglutamyl peptide hydrolyzing (PGPH) activities of the proteasome. It modifies the proteasomal catalytic subunits LMP-7, MECL1, and Z[MJ2] .

Application

Epoxomicin has been used incell culture for proteasome inhibition experiments.[1] It has also been used incell culture medium to treat MODE-K cells for stimulation to blockproteasome.

Packaging

Packaged under inert gas

Physical form

A 1 mM (50 µg/90 µl) solution of Epoxomicin, Synthetic (Cat. No. 324800) in DMSO.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk: WGK 1
• flash_point_f: 188.6 °F - closed cup - (Dimethylsulfoxide)
• flash_point_c: 87 °C - closed cup - (Dimethylsulfoxide)