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317700

Dkk-1 Inhibitor, WAY-262611, HCl

The Dkk-1 Inhibitor, WAY-262611 controls the biological activity of Dkk-1.

Synonym(s):

Dkk-1 Inhibitor, WAY-262611, HCl, (1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine, Wnt Pathway Activator VI

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Size/SKUAvailabilityPrice
10 mg

Available to ship TODAYfromAreál Kühne+Nagel spol. s r.o.

CZK 4,990.00

About This Item

Empirical Formula (Hill Notation):
C20H22N4 · xHCl
Molecular Weight:
318.42 (free base basis)
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
powder
Storage condition:
OK to freeze, protect from light

CZK 4,990.00

Available to ship TODAYDetails

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Quality Segment

100

assay

≥95% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: 25 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

A 2-aminopyrimidine compound that counteracts the antagonizing effect of Dkk-1 (Dickkopf-1) against Wnt-3a/LRP5 interaction and prevents Dkk-1-mediated Kr2/LRP5/Dkk-1 complex formation and internalization. Shown to successfully rescue cellular response to Wnt-3a stimulation in the presence of Dkk-1 (EC50 = 0.63 µM in a cell-based TCF-luciferase assay) in vitro and double the tibia trabecular bone formation in OVX rats in a period of 28 days via an oral dose of 10 mg/kg/day in vivo.

Packaging

Packaged under inert gas

Other Notes

Pelletier, J.C., et al. 2009. J. Med. Chem.52, 6962.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Dkk-1 Inhibitor, WAY-262611, HCl The Dkk-1 Inhibitor, WAY-262611 controls the biological activity of Dkk-1.

Sigma-Aldrich

317700

Dkk-1 Inhibitor, WAY-262611, HCl

Dkk Inhibitor II, IIIC3a

Sigma-Aldrich

317701

Dkk Inhibitor II, IIIC3a

Wnt Agonist II, SKL2001 The Wnt Agonist II, SKL2001 controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Biochemicals applications.

Sigma-Aldrich

681667

Wnt Agonist II, SKL2001

Wnt Pathway Inhibitor XI, CCT036477 The Wnt Pathway Inhibitor XI, CCT036477, also referenced under CAS 305372-78-5, controls the biological activity of Wnt Pathway. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

681674

Wnt Pathway Inhibitor XI, CCT036477

form

powder

form

powder

form

solid

form

solid

assay

≥95% (HPLC)

assay

≥90% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (1H-NMR)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 25 mg/mL

solubility

DMSO: 10 mg/mL, hydrogen: 2.5 mg/mL

solubility

DMSO: 100 mg/mL, clear, red

solubility

DMSO: 50 mg/mL

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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