Skip to Content
Merck

Key Documents

View All Documentation

Skip To

681674

Wnt Pathway Inhibitor XI, CCT036477

The Wnt Pathway Inhibitor XI, CCT036477, also referenced under CAS 305372-78-5, controls the biological activity of Wnt Pathway. This small molecule/inhibitor is primarily used for Cancer applications.

Synonym(s):

Wnt Pathway Inhibitor XI, CCT036477, CCT036477, CRT Inhibitor VI, β-Catenin/Tcf Inhibitor VI

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Size/SKUAvailabilityPrice
5 mg

Estimated to ship onJune 10, 2026fromAreál Kühne+Nagel spol. s r.o.

CZK 3,620.00

About This Item

Empirical Formula (Hill Notation):
C21H18ClN3
CAS Number:
305372-78-5
Molecular Weight:
347.84
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD01831143
Assay:
≥95% (1H-NMR)
Form:
solid
Storage condition:
OK to freeze, protect from light

CZK 3,620.00

Estimated to ship onJune 10, 2026Details

​
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Segment

100

assay

≥95% (1H-NMR)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

off-white

solubility

DMSO: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

Clc1ccc(cc1)C(Nc4ncccc4)c2c3c([nH]c2C)cccc3

InChI

1S/C21H18ClN3/c1-14-20(17-6-2-3-7-18(17)24-14)21(15-9-11-16(22)12-10-15)25-19-8-4-5-13-23-19/h2-13,21,24H,1H3,(H,23,25)

InChI key

IFOHRIXRQPOHQZ-UHFFFAOYSA-N

General description

A cell-permeable indole derivative that acts as an inhibitor of Wnt signaling and exhibits an inhibitory effect in a reporter cell line (IC50 = 4.6 µM) and demonstrates growth inhibition in multiple cancer cell lines, not by altering β-catenin accumulation but by blocking transcription at the β-catenin level. Displays reduced expression of Wnt target genes in myc and survivin-luciferase reporter assays, and exhibits in vivo activity by blocking the development of zebrafish at 20 µM and Xenopus embryos at 75 µM.

Packaging

Packaged under inert gas

Preparation Note

Following recontitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Ewan, K., et al. 2010. Cancer Res.70, 5963.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
681665219332681669
Wnt Pathway Inhibitor XI, CCT036477 The Wnt Pathway Inhibitor XI, CCT036477, also referenced under CAS 305372-78-5, controls the biological activity of Wnt Pathway. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

681674

Wnt Pathway Inhibitor XI, CCT036477

Wnt Agonist The Wnt Agonist, also referenced under CAS 853220-52-7, controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

681665

Wnt Agonist

β-Catenin/Tcf Inhibitor III, iCRT3 The β-Catenin/Tcf Inhibitor III, iCRT3 controls the biological activity of β-Catenin/Tcf. This small molecule/inhibitor is primarily used for Biochemicals applications.

Sigma-Aldrich

219332

β-Catenin/Tcf Inhibitor III, iCRT3

Wnt Antagonist I, IWR-1-endo Wnt Antagonist I, IWR-1-endo, is a cell-permeable inhibitor of TNKS1/PARP5a (IC50 = 131 nM) & TNKS2/PARP5b (IC50 = 56 nM). Suppress Wnt-stimulated transcription activity (IC50 = 180 nM).

Sigma-Aldrich

681669

Wnt Antagonist I, IWR-1-endo

assay

≥95% (1H-NMR)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

form

solid

form

solid (sticky)

form

powder

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

DMSO: 50 mg/mL

solubility

DMSO: 10 mg/mL, ethanol: 5 mg/mL

solubility

DMSO: 50 mg/mL

solubility

DMSO: 10 mg/mL

Storage Class

11 - Combustible Solids

wgk

WGK 2

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Questions

Reviews

No rating value

Active Filters