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23-027-M

b-catenin Protein, activated, 10 µg

Activated, full length, recombinant human β-catenin. N-terminal c-Myc, 6His-tagged. Phosphorylated in vitro using GSK-3a (Item # 14-492). For use in Enzyme Assays. Behaves as a substrate in ubiquitin assays.

Synonym(s):

Catenin beta-1

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Pack SizeSKUAvailabilityPrice
10 μg

Available to ship TODAYfromAreál Kühne+Nagel spol. s r.o.

CZK 17,400.00
250 μg

Estimated to ship onMay 07, 2026fromAreál Kühne+Nagel spol. s r.o.

CZK 99,000.00

About This Item

UNSPSC Code:
12352202
NACRES:
NA.41
eCl@ss:
32160405
Biological source:
human
Recombinant:
expressed in Sf21 cells

CZK 17,400.00

Available to ship TODAYDetails

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biological source

human

Quality Level

100, 300

recombinant

expressed in Sf21 cells

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable

NCBI accession no.

NM_001904

General description

β-catenin is a multifunctional protein; it is a central component of the cadherin cell adhesion complex, regulating the control of cell adhesion and plays an essential role in the Wingless/Wnt signaling pathway that governs cell fate in early embryogenesis. The regulation of β-catenin turnover in the cells is governed by its phosphorylation status which allows the targeting of ubiquitin-dependent proteolysis. Altered levels of protein expression as well as genetic mutations of β-catenin have been implicated in a number of human cancers.
N-terminal GST-tagged, recombinant human Smurf1 full length, expressed in E coli.

Application

Ubiquitination Cascade Comoponent: Substrate

Physical form

Purified using immobilized metal affinity chromatography.

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item
05-665-AF55505-665-AF64705-665-AF488
b-catenin Protein, activated, 10 µg Activated, full length, recombinant human β-catenin. N-terminal c-Myc, 6His-tagged. Phosphorylated in vitro using GSK-3a (Item # 14-492). For use in Enzyme Assays. Behaves as a substrate in ubiquitin assays.

Sigma-Aldrich

23-027-M

b-catenin Protein, activated, 10 µg

Anti-Active-β-Catenin Antibody, clone 8E7, Alexa Fluor™ 555 clone 8E7, from mouse, ALEXA FLUOR™ 555

Sigma-Aldrich

05-665-AF555

Anti-Active-β-Catenin Antibody, clone 8E7, Alexa Fluor™ 555

Anti-Active-β-Catenin Antibody, clone 8E7, Alexa Fluor™ 647 clone 8E7, from mouse, ALEXA FLUOR™ 647

Sigma-Aldrich

05-665-AF647

Anti-Active-β-Catenin Antibody, clone 8E7, Alexa Fluor™ 647

Anti-Active-β-Catenin Antibody, clone 8E7, Alexa Fluor™ 488 clone 8E7, from mouse, ALEXA FLUOR™ 488

Sigma-Aldrich

05-665-AF488

Anti-Active-β-Catenin Antibody, clone 8E7, Alexa Fluor™ 488

biological source

human

biological source

mouse

biological source

mouse

biological source

mouse

technique(s)

activity assay: suitable

technique(s)

immunocytochemistry: suitable, immunohistochemistry: suitable

technique(s)

flow cytometry: suitable, immunocytochemistry: suitable

technique(s)

flow cytometry: suitable, immunocytochemistry: suitable, immunohistochemistry: suitable

recombinant

expressed in Sf21 cells

recombinant

-

recombinant

-

recombinant

-

NCBI accession no.

NM_001904

NCBI accession no.

NP_001895

NCBI accession no.

NP_001895

NCBI accession no.

NP_001895

Quality Level

100, 300

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Upstate®

manufacturer/tradename

-

manufacturer/tradename

-

manufacturer/tradename

-

Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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?-Catenin signaling is a critical event in ErbB2-mediated mammary tumor progression.
Schade, Babette, et al.
Cancer Research, 73, 4474-4487 (2013)

Global Trade Item Number

SKUGTIN
23-027M04053252294433
23-02704053252294723

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