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219461

Cathepsin K, His•Tag®, Human, Recombinant, E. coli

Cathepsin K, His•Tag, Human, Recombinant, E. coli, CAS 94716-09-3, of the papain superfamily of cysteine proteinases plays a role in osteoclast-mediated bone resorption and collagen degradation.

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Size/SKUAvailabilityPrice
25 μg

Estimated to ship onMay 25, 2026fromAreál Kühne+Nagel spol. s r.o.

CZK 8,520.00

About This Item

CAS Number:
94716-09-3
EC Number:
3.4.22.38 (BRENDA, IUBMB)
NACRES:
NA.77
UNSPSC Code:
12352202
MDL number:
MFCD00011084
Form:
liquid
Assay:
≥95% (SDS-PAGE)
Recombinant:
expressed in E. coli

CZK 8,520.00

Estimated to ship onMay 25, 2026Details

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recombinant

expressed in E. coli

Quality Segment

100

assay

≥95% (SDS-PAGE)

form

liquid

specific activity

≥900 mU/mg protein

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, avoid repeated freeze/thaw cycles

shipped in

wet ice

storage temp.

−70°C

General description

Cathepsin K is a member of the papain superfamily of cysteine proteinases and plays an important role in osteoclast-mediated bone resorption and collagen degradation. It is primarily expressed by osteoclasts and recent studies also suggest its expression in fibroblasts. Irregularities in cathepsin K activity, either too high or too low, contribute to osteopenic disorders such as osteoporosis and pycnodysostosis. This recombinant enzyme contains a C-terminal His•Tag sequence.
Note: 1 mU = 1 milliunit.

Packaging

Please refer to vial label for lot-specific concentration.

Physical form

In 50 mM NaOAC, pH 5.5. The activation was stopped by addition of 10 mM MMTS, which can be removed under reducing conditions.

Preparation Note

Following initial thaw, aliquot and freeze (-70°C).

Other Notes

Delaisse, J.M., et al. 2003. Microsc. Res. Tech.61, 504.
Dodds, R.A. 2003. Cell Biochem. Funct.21, 231.
Everts, V., et al. 2003. Calcif. Tissue Int.73, 380.
Hou, W.S., et al. 2003. Biol. Chem.384, 891.
One unit is defined as the amount of enzyme that will hydrolyze 0.4 µmol Z-FR-AMC per min at 37°C, pH 5.5.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
HIS TAG is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Cathepsin K, His•Tag®, Human, Recombinant, E. coli Cathepsin K, His•Tag, Human, Recombinant, E. coli, CAS 94716-09-3, of the papain superfamily of cysteine proteinases plays a role in osteoclast-mediated bone resorption and collagen degradation.

Sigma-Aldrich

219461

Cathepsin K, His•Tag®, Human, Recombinant, E. coli

Procathepsin K, Human, Recombinant, E. coli Recombinant, human procathepsin K expressed in E. coli with a methionine residue inserted at amino acid 18 to create a new N-terminal initiation site.

Sigma-Aldrich

342001

Procathepsin K, Human, Recombinant, E. coli

Cathepsin S, Human, Recombinant, E. coli Cathepsin S, Human, Recombinant, E. coli, is prepared without a tag or fusion protein. A major lysosomal cysteine proteinase with high specific activity.

Sigma-Aldrich

219343

Cathepsin S, Human, Recombinant, E. coli

Galectin-3C, Human, Recombinant, E. coli

Sigma-Aldrich

345832

Galectin-3C, Human, Recombinant, E. coli

assay

≥95% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

assay

≥90% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

-

form

liquid

form

liquid

form

liquid

form

lyophilized

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

specific activity

≥900 mU/mg protein

specific activity

≥1000 mU/mg protein

specific activity

≥30,000 mU/mg protein

specific activity

-

storage temp.

−70°C

storage temp.

−70°C

storage temp.

−70°C

storage temp.

−20°C

Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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