Complement iC3b, Human, is a native form that is formed by the cleavage of C3b by Factor I in the presence of Factor H, CR1, or membrane cofactor protein.
Synonym(s):
Complement iC3b, Human Complement iC3b, Human iC3b
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
Size/SKU
Availability
Price
250 μg
204863-250UG
Estimated to ship onMay 25, 2026fromAreál Kühne+Nagel spol. s r.o.
Native, human iC3b complement component. iC3b is formed by the cleavage of C3b by Factor I in the presence of Factor H, CR1, or membrane cofactor protein. Factor I cleavage of C3b to iC3b inactivates and prevents C3b from functioning in the C3 or C5 convertase enzymes. The iC3b fragment thus produced is a glycoprotein composed of two C3α′ polypeptides of M.W. 43 kDa and M.W. 63 kDa which are disulfide bonded to the intact C3 β-chain (M.W. 75 kDa). iC3b interaction with CR3 (CD11b/CD18) receptors present on a variety of white blood cells greatly enhances phagocytosis of iC3b coated target cells or particles.
Packaging
Please refer to vial label for lot-specific concentration.
Other Notes
Rosen, H. and Law, S.K.A. 1989. Curr. Top. Microbiol. Immunol.153, 99. Ross, G.S. and Medof, M.E. 1985. Adv. Immunol.37, 217.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.