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203389

Blebbistatin, Racemic

≥97% (HPLC), liquid, Myosin II inhibitor, Calbiochem®

Synonym(s):

InSolutionBlebbistatin, Racemic

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Pack SizeSKUAvailabilityPrice
5 mg
Please contact Customer Service for Availability
CZK 6,380.00

About This Item

Empirical Formula (Hill Notation):
C18H16N2O2
Molecular Weight:
292.33
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥97% (HPLC)
Form:
liquid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light

CZK 6,380.00

Please contact Customer Service for Availability
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Product Name

Blebbistatin, Racemic, InSolution, ≥97%, 50 mM in 90% DMSO, reversible inhibitor of nonmuscle myosin II

Quality Segment

100

assay

≥97% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

shipped in

wet ice

storage temp.

−20°C

General description

A cell-permeable compound that acts as a selective, potent, and reversible inhibitor of non-muscle myosin II. Inhibits the ATPase and gliding motility of human platelets (≤100 µM) without affecting myosin light chain kinase (MLCK) activity. Has been shown to block cell blebbing and to rapidly disrupt directed cell migration and cytokinesis in vertebrate cells. Does not disrupt mitosis or affect contractile ring assembly.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
ATPase
Product does not compete with ATP.
Reversible: yes
Target IC50: <100 µM inhibiting the ATPase and gliding motility of human platelets

Packaging

Packaged under inert gas

Physical form

A 50 mM (5 mg/342 µl) solution of (±)-Blebbistatin (Cat. No. 203390 ) in 90% DMSO.

Preparation Note

Following initial thaw, aliquot and freeze (-20°C).

Other Notes

Shu, S., et al. 2005. Proc. Natl. Acad. Sci. USA102, 1472.
Kovacs, M., et al. 2004. J. Biol. Chem.279, 35557.
Straight, A.F., et al. 2003. Science299, 1743.
Cheung, A., et al. 2001. Mol. Biol. Cell Suppl.12, 271a.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

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This Item
203390203895124015
Blebbistatin, Racemic InSolution, &#8805;97%, 50 mM in 90% DMSO, reversible inhibitor of nonmuscle myosin II

Sigma-Aldrich

203389

Blebbistatin, Racemic

(±)-Blebbistatin (&#177;)-Blebbistatin, CAS 674289-55-5, is a cell-permeable, selective, and reversible inhibitor of nonmuscle myosin II. Blocks cell blebbing and disrupts cell migration &amp; cytoKinesis in vertebrate cells.

Sigma-Aldrich

203390

(±)-Blebbistatin

BTS A potent inhibitor of Ca2+-stimulated myosin S1 ATPase (IC50 = ~ 5 &#181;M) and reversibly blocks the gliding motility.

Sigma-Aldrich

203895

BTS

Akt Inhibitor IV InSolution, &#8805;98%

Sigma-Aldrich

124015

Akt Inhibitor IV

form

liquid

form

solid

form

crystalline solid

form

liquid

assay

≥97% (HPLC)

assay

≥97% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

OK to freeze, protect from light, desiccated (hygroscopic)

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

188.6 °F - closed cup - (Dimethylsulfoxide)

flash_point_c

87 °C - closed cup - (Dimethylsulfoxide)

Certificates of Analysis (COA)

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Global Trade Item Number

SKUGTIN
203389-5MG04055977221251

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