16-246

Anti-EGFR Antibody, neutralizing, clone LA1, Alexa Fluor^™ 488

clone LA1, Upstate^®, from mouse

• UNSPSC Code: 12352203
• NACRES: NA.41
• eCl@ss: 32160702
• Conjugate: ALEXA FLUOR^™ 488
• Clone: LA1, monoclonal
• Application: IF
• Citations: 10

Properties

• biological source: mouse
• Quality Segment: 100
• conjugate: ALEXA FLUOR^™ 488
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: LA1, monoclonal
• species reactivity: human, mouse, rat
• manufacturer/tradename: Upstate^®
• technique(s): immunofluorescence: suitable
• isotype: IgG1
• NCBI accession no.: NM_005228.3, NM_201282.1, NM_201283.1, NM_201284.1
• UniProt accession no.: P00533
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... EGFR(1956) ; mouse ... Egfr(13649) ; rat ... Egf(25313)

Description

General description

Included Negative Control: Catalog # 16-240, Alexa Fluor^™ 488-conjugated Normal Mouse IgG.

Inhibits A431 cell growth. Recognizes an antigenic determinant located on the extracellular domain of the receptor.

Immunogen

Human A431 membrane proteins

Application

Research Category
Signaling

Research Sub Category
Growth Factors & Receptors

This Anti-EGFR Antibody, neutralizing, clone LA1, Alexa Fluor 488 is validated for use in IF for the detection of EGFR.

Biochem/physiol Actions

external domain of EGF receptor on all human cells. Competes with EGF and TGF-α for binding on human cells. Recognizes both phosphorylated and non-phosphorylated human EGF receptors.

Preparation Note

1 year at 4°C from date of shipment

Analysis Note

Routinely evaluated by positive immunostaining for the EGF receptor in A431 cells.

Legal Information

ALEXA FLUOR is a trademark of Life Technologies

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Alexa Fluor^™ is a registered trademark of Molecular Probes, Inc.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable