Key Documents

ErbB2, active

Select a Size

Change View

Size/SKU	Availability	Price
10 μg	Estimated to ship onJune 05, 2026fromAreál Kühne+Nagel spol. s r.o.	CZK 14,700.00
250 μg	Estimated to ship onJune 09, 2026fromAreál Kühne+Nagel spol. s r.o.	CZK 93,000.00

About This Item

UNSPSC Code:

12352202

NACRES:

NA.32

eCl@ss:

32160405

Biological source:

human

CZK 14,700.00

Estimated to ship onJune 05, 2026Details

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

biological source

human

Quality Segment

100

mol wt

M_w 69 kDa

manufacturer/tradename

Upstate^®

technique(s)

activity assay: suitable (kinase)

NCBI accession no.

NM_004448 (G778D)

Description

General description

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization

Application

Research Category
Signaling

Biochem/physiol Actions

Protein Target: ErbB2

Target Sub-Family: TK

Packaging

Also available in 250μg size as catalog # 14-939M and in bulk as catalog # 14-939-K.

Physical form

Protein in 50mM Tris/HCl pH7.5, 150mM NaCl, 0.5mM EDTA, 0.01% CHAPS, 50% glycerol, 2mM DTT. Frozen solution.

Purified using immobilized metal affinity chromatography.

Preparation Note

6 months at -70°C

Analysis Note

Routinely evaluated by phosphorylation of poly(Glu, Tyr) (4:1)

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item	MABE330	05-1133	MABE320
Sigma-Aldrich 14-939-M ErbB2, active	Sigma-Aldrich MABE330 Anti-c-ErbB2/c-Neu Antibody, clone 3B5	Sigma-Aldrich 05-1133 Anti-erbB4 Antibody, clone HFR1/2G4	Sigma-Aldrich MABE320 Anti-c-ErbB2/c-Neu (Ab-5) Antibody, clone TA-1
technique(s) activity assay: suitable (kinase)	technique(s) immunohistochemistry: suitable, western blot: suitable	technique(s) immunohistochemistry: suitable (paraffin), immunoprecipitation (IP): suitable, western blot: suitable	technique(s) flow cytometry: suitable, immunofluorescence: suitable, immunoprecipitation (IP): suitable, western blot: suitable
biological source human	biological source mouse	biological source mouse	biological source mouse
mol wt M_w 69 kDa	mol wt -	mol wt -	mol wt -
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
manufacturer/tradename Upstate^®	manufacturer/tradename -	manufacturer/tradename -	manufacturer/tradename -
NCBI accession no. NM_004448 (G778D)	NCBI accession no. NP_001005862	NCBI accession no. NP_005226.1	NCBI accession no. NP_001005862

Storage Class

10 - Combustible liquids

wgk

WGK 1

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.