14-520-M

Casein Kinase 1δ (aa 1-294) Protein, active, 10 µg

Active, N-terminal, GST-tagged, recombinant human CK1 delta, amino acids 1-294, for use in Kinase Assays.

• Synonym(s): Kinase protein
• UNSPSC Code: 12352202
• NACRES: NA.32
• eCl@ss: 32160405
• Biological source: human
• Recombinant: expressed in E. coli

Properties

• biological source: human
• Quality Segment: 100
• recombinant: expressed in E. coli
• mol wt: M_w 61 kDa
• manufacturer/tradename: Upstate^®
• technique(s): activity assay: suitable (kinase)
• NCBI accession no.: NM_001893.3, NM_139062.1
• UniProt accession no.: P48730
• Gene Information: human ... CSNK1D(1453)

Description

General description

Research area: Cell signaling

Research Category: Metabolism Research

Subcategory: Obesity

Protein Target: CK1γδ

Target Sub-Family: CK1

Casein Kinase 1δ (CK1δ ) is a serine/threonine kinase that belong to the family of casein kinase 1.[1] The protein structure consists of anti-parallel β-sheet strands at N-terminal lobe (N-lobe) and α-helices and loop structures at the larger C-terminal lobe (C-lobe).

Application

Research Category
Metabolism

Research Sub Category
Obesity

Metabolic Disorders

Biochem/physiol Actions

Casein Kinase 1δ (CK1δ) is implicated in multiple cellular processes, including membrane trafficking, cytokinesis, circadian rhythm, and tumorigenesis. It interacts with critical molecules within cancer-related signaling pathways, such as Wnt/β-catenin, PI3K/AKT, and Hedgehog. Therefore, mutations or overexpression of the CK1δ coding gene can potentially contribute to the onset and progression of cancer.[1]

Packaging

Also available in 250 µg size --call for pricing and availability and reference catalog number 14-520M when ordering the 250 µg size.

Physical form

Glutathione-agarose

Preparation Note

6 months at -20°C

Analysis Note

routinely evaluated by phosphorylation of KRRRALS(p)VASLPGL

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H317
• pcodes: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Storage Class: 10 - Combustible liquids
• wgk: WGK 2