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114802

AdaAhx3L3VS

A potent, covalent, cell-permeable, irreversible inhibitor of chymotrypsin-like (50-100 nM), trypsin-like (1-5 µM), and PGPH (0.5-1 µM) activities of the 20S proteasome.

Synonym(s):

AdaAhx3L3VS, Adamantane-acetyl-(6-aminohexanoyl)₃-(leucinyl)3-vinyl-(methyl)-sulfone, Proteasome Inhibitor XVI

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250 μg

Estimated to ship onMay 04, 2026fromAreál Kühne+Nagel spol. s r.o.

CZK 9,730.00

About This Item

Empirical Formula (Hill Notation):
C50H88N6O8S
CAS Number:
389064-25-9
Molecular Weight:
933.33
MDL number:
MFCD00036390
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥90% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
OK to freeze, protect from light

CZK 9,730.00

Estimated to ship onMay 04, 2026Details

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Quality Level

100

assay

≥90% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

off-white

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

A cell-permeable, peptide vinyl sulfone that acts as a potent, irreversible inhibitor of proteasome activity. Covalently modifies the catalytically active β-subunits of the proteasome. Shown to inhibit the chymotrypsin-like (10-50 nM), trypsin-like (1-5 µM), and the peptidyl glutamyl peptide hydrolyzing (PGPH) (0.5-1 µM) activities of purified 20S proteasomes from rabbit muscle. Inhibits proteasomal degradation of deglycosylated MHC HLA-A2 heavy chain in US11+ cells (~50 µM).
A potent, covalent, cell-permeable, irreversible inhibitor of chymotrypsin-like (50-100 nM), trypsin-like (1-5 µM), and PGPH (0.5-1 µM) activities of the 20S proteasome.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
chymotrypsin-like activity of the 20S proteasome
Product does not compete with ATP.
Reversible: no
Target IC50: 50-100 nM against chymotrypsin-like activity of the 20S proteasome

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Kessler, B.M., et al. 2001. Chem. Biol.8, 913.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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539162539160208743
AdaAhx3L3VS A potent, covalent, cell-permeable, irreversible inhibitor of chymotrypsin-like (50-100 nM), trypsin-like (1-5 µM), and PGPH (0.5-1 µM) activities of the 20S proteasome.

Sigma-Aldrich

114802

AdaAhx3L3VS

Proteasome Inhibitor II The Proteasome Inhibitor II controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Sigma-Aldrich

539162

Proteasome Inhibitor II

Proteasome Inhibitor I The Proteasome Inhibitor I controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Sigma-Aldrich

539160

Proteasome Inhibitor I

Calpain Inhibitor XI The Calpain Inhibitor XI, also referenced under CAS 145731-49-3, controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Sigma-Aldrich

208743

Calpain Inhibitor XI

form

powder

form

lyophilized solid

form

solid

form

solid

assay

≥90% (HPLC)

assay

≥95% (HPLC)

assay

≥90% (HPLC)

assay

≥95% (HPLC)

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, desiccated

storage condition

OK to freeze

storage condition

OK to freeze, desiccated (hygroscopic)

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Global Trade Item Number

SKUGTIN
114802-250UG04055977208108

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