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Anti-EED Antibody

Name: Anti-EED Antibody
Brand: MM
Price: 14300 CZK
Availability: InStock

from rabbit

Synonym(s):

embryonic ectoderm development

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Pack Size	SKU	Availability	Price
100 μg		Estimated to ship onJune 02, 2026fromAreál Kühne+Nagel spol. s r.o.	CZK 14,300.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Conjugate:

unconjugated

Clone:

polyclonal

Application:

Citations:

CZK 14,300.00

Estimated to ship onJune 02, 2026Details

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Properties

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, mouse

species reactivity (predicted by homology)

dog, chicken, bovine, opossum, rat

technique(s)

western blot: suitable

NCBI accession no.

NP_003788

UniProt accession no.

O75530

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

dog ... Eed(476779)
human ... EED(8726)
mouse ... Eed(13626)
rat ... Eed(293104)

Description

General description

Polycomb group proteins are important for maintaining transcriptional silencing. One conserved PcG complex, PRC2, is composed of several proteins including the histone methyltransferase EZH2, the WD-repeat protein EED (Embryonic ectoderm development), and the Zn-finger protein Suz12. Transcriptional repression mediated by EED involves histone deacetylation, while the EZH2 methylates histone H3 on lysine 27. EED protein is present in four isoforms. These EED isoforms selectively associate with distinct EZH2-containing complexes, resulting in differential targeting of their associated methyltransferase activity. These complexes play a role in Hox gene silencing, X-inactivation, germline development, stem cell pluripotency and cancer metastasis.

~53 kDa observed. Uniprot describes three isoforms at 51 kDa (isoform 1), 53 kDa (isoform 2), and 46 kDa (isoform 3).

Immunogen

A synthetic peptide corresponding to a.a. 429-441 of human EED, conjugated to KLH.

Epitope: a.a. 429-441

Application

Use Anti-EED Antibody (Rabbit Polyclonal Antibody) validated in WB to detect EED also known as embryonic ectoderm development.

Biochem/physiol Actions

This antibody recognizes EED, Mr ~ 62-70 kDa.

Physical form

Format: Purified

Analysis Note

Control
Jurkat Cell Lysate

3T3/A31 cell lysate

Western Blot Analysis: 1 μg/mL of this lot detected EED on 10 μg of Jurkat cell lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Replaces: 09-727

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Show Differences

1 of 1

This Item	07-689	05-1319	ABE1069
Sigma-Aldrich 09-774 Anti-EED Antibody	Sigma-Aldrich 07-689 Anti-EZH2 Antibody	Sigma-Aldrich 05-1319 Anti-EZH2 Antibody, clone BD43	Sigma-Aldrich ABE1069 Anti-Polyhomeotic-like protein 2 Antibody (PHC2)
antibody form purified antibody	antibody form whole antiserum	antibody form purified immunoglobulin	antibody form affinity isolated antibody
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
species reactivity human, mouse	species reactivity human, mouse	species reactivity human, mouse	species reactivity human, rat, mouse
clone polyclonal	clone polyclonal	clone BD43, monoclonal	clone polyclonal
biological source rabbit	biological source rabbit	biological source mouse	biological source rabbit
technique(s) western blot: suitable	technique(s) ChIP: suitable (ChIP-seq), immunoprecipitation (IP): suitable, western blot: suitable	technique(s) western blot: suitable	technique(s) immunohistochemistry: suitable, western blot: suitable

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ezh2 expression in astrocytes induces their dedifferentiation toward neural stem cells.

Falak Sher et al.

Cellular reprogramming, 13(1), 1-6 (2010-10-29)

Recently, we have demonstrated the expression of the polycomb group protein Ezh2 in embryonic and adult neural stem cells. Although Ezh2 remained highly expressed when neural stem cells differentiate into oligodendrocyte precursor cells, it is downregulated during the differentiation into

Polycomb repressive complex 1 shapes the nucleosome landscape but not accessibility at target genes.

Hamish W King et al.

Genome research, 28(10), 1494-1507 (2018-08-30)

Polycomb group (PcG) proteins are transcriptional repressors that play important roles in regulating gene expression during animal development. In vitro experiments have shown that PcG protein complexes can compact chromatin to limit the activity of chromatin remodeling enzymes and access

Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling.

Fatemeh Mirzamohammadi et al.

Nature communications, 7, 12047-12047 (2016-06-23)

Polycomb repressive complex 2 (PRC2) controls maintenance and lineage determination of stem cells by suppressing genes that regulate cellular differentiation and tissue development. However, the role of PRC2 in lineage-committed somatic cells is mostly unknown. Here we show that Eed