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857136P

Avanti

18:1 BMP (R,R)

sn-(1-oleoyl-2-hydroxy)-glycerol-3-phospho-sn-3′-(1′-oleoyl-2′-hydroxy)-glycerol (ammonium salt), powder

Synonym(s):

lysobisphosphatidic acid; LBPA

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About This Item

Empirical Formula (Hill Notation):
C42H82NO10P
CAS Number:
1246303-13-8
Molecular Weight:
792.07
UNSPSC Code:
51191904
NACRES:
NA.25

Assay

>99% (BMP (contains 30% positional isomers), TLC)

form

powder

packaging

pkg of 1 × 5 mg (857136P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 857136P

lipid type

phospholipids
cardiolipins

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP(OC[C@]([H])(O)COC(CCCCCCC/C=C\CCCCCCCC)=O)([O-])=O)(O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[NH4+]

General description

Bis(monoacylglycerol)phosphate (BMP) is an acidic phospholipid. It is mostly located in the lysosomal and endosomal compartments within cells.

Biochem/physiol Actions

Bis(monoacylglycerol)phosphate (BMP) regulates late endosomes/lysosomes (LE/Lys) degradation pathway. It also modulates cholesterol homeostasis and trafficking of lysosomal enzymes. BMP is implicated in the digestion and recycling of membranous materials and synthesis of intra luminal vesicles.

Packaging

5 mL Clear Glass Sealed Ampule (857136P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ion mobility and tandem mass spectrometry of phosphatidylglycerol and bis (monoacylglycerol) phosphate (BMP)
Hankin JA, et al.
International Journal of Mass Spectrometry, 378, 255-263 (2015)
Nanjun Liu et al.
Toxicology and applied pharmacology, 279(3), 467-476 (2014-06-27)
The inability to routinely monitor drug-induced phospholipidosis (DIPL) presents a challenge in pharmaceutical drug development and in the clinic. Several nonclinical studies have shown di-docosahexaenoyl (22:6) bis(monoacylglycerol) phosphate (di-22:6-BMP) to be a reliable biomarker of tissue DIPL that can be
Elena Zaitseva et al.
PLoS pathogens, 6(10), e1001131-e1001131 (2010-10-16)
Many enveloped viruses invade cells via endocytosis and use different environmental factors as triggers for virus-endosome fusion that delivers viral genome into cytosol. Intriguingly, dengue virus (DEN), the most prevalent mosquito-borne virus that infects up to 100 million people each

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