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  • Automated Solid-Phase Click Synthesis of Oligonucleotide Conjugates: From Small Molecules to Diverse N-Acetylgalactosamine Clusters.

Automated Solid-Phase Click Synthesis of Oligonucleotide Conjugates: From Small Molecules to Diverse N-Acetylgalactosamine Clusters.

Bioconjugate chemistry (2017-09-19)
Valentina M Farzan, Egor A Ulashchik, Yury V Martynenko-Makaev, Maksim V Kvach, Ilya O Aparin, Vladimir A Brylev, Tatiana A Prikazchikova, Svetlana Yu Maklakova, Alexander G Majouga, Alexey V Ustinov, German A Shipulin, Vadim V Shmanai, Vladimir A Korshun, Timofei S Zatsepin
ANOTACE

We developed a novel technique for the efficient conjugation of oligonucleotides with various alkyl azides such as fluorescent dyes, biotin, cholesterol, N-acetylgalactosamine (GalNAc), etc. using copper-catalysed alkyne-azide cycloaddition on the solid phase and CuI·P(OEt)

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Sigma-Aldrich
Cy5-azide, 95% (HPLC)
Sigma-Aldrich
Coumarin 343, Dye content 97 %